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STRUCTURAL MODIFICATION AND BIOACTIVITY OF PERLOLYRINE
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 7
- DOI:
- 10.3321/j.issn:0513-4870.1999.07.005
- Key Word:
- 川芎哚;结构改造;抗血小板聚集;抗血栓
Abstract： 目的:寻找新型的心血管药物.方法:根据推理药物设计原理,设计合成目标化合物,并研究其生物活性.结果:合成了16个川芎哚的类似物(I～XVI),其中8个化合物(I,II,V～VII,IX,XI和XV)是新化合物.结论:所合成的川芎哚类似物均有一定程度的抗血小板聚集作用,其中I～IV,VII,X,XI及XIII有一定程度的抗血栓作用.
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