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SKELETAL EFFECTS OF PREDNISONE ACETATE ON TRABECULAR AND CORTICAL BONE IN SPRAGUE-DAWLEY RATS
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 7
- DOI:
- 10.3321/j.issn:0513-4870.1999.07.004
- Key Word:
- 骨质疏松;醋酸泼尼松;骨组织形态计量学
Abstract： 目的:比较醋酸泼尼松对大鼠胫骨上段和腰椎松质骨及胫骨中段密质骨的影响. 方法:醋酸泼尼松4.5 mg.kg-1,ig, 1周2次共90 d. 骨标本行不脱钙骨制片,骨组织形态计量学测量. 结果:松质骨:激素组与对照组比,胫骨上段(PTM)和腰椎(LV) 松质骨的骨量减少,骨结构变差;代表骨形成的参数值降低,而骨吸收参数值增加.与自身对照组比, PTM骨量减少40%, LV骨量减少28%. 密质骨:激素组与对照组比,实验90 d骨量未出现减少.骨外膜面代表骨形成的参数减少,骨内膜骨吸收参数增加.结论:醋酸泼尼松以抑制骨形成、促进骨吸收而致骨丢失.
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