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EFFECTS OF ISORHAPOTIGENIN AND RESVERATROL ON INTERLEUKIN 6 mRNA EXPRESSION FROM STIMULATED PERITONEAL MACROPHAGES OF MICE
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 5
- DOI:
- 10.3321/j.issn:0513-4870.1999.05.003
- Key Word:
- 白细胞介素6mRNA;白藜芦醇;异丹叶大黄素;逆转录聚合酶链式反应(RT-PCR)
Abstract： 目的:观察异丹叶大黄素和白藜芦醇对分别由炎性三肽(fMLP)和钙离子载体A23187(A23187)诱导的小鼠腹腔巨噬细胞白细胞介素6(interleukin 6, IL-6) mRNA表达水平的影响.方法:用半定量mRNA的RT-PCR.结果:异丹叶大黄素和白藜芦醇在2×10-6和2×10-5 mol.L-1浓度下,均能抑制fMLP和A23187诱导的小鼠腹腔巨噬细胞IL-6 mRNA的表达.结论:该2个化合物抑制IL-6活性的作用机制之一是抑制IL-6 mRNA表达.
- [1]钟淼,程桂芳,王文杰,等.4种刺激剂对小鼠腹腔巨噬细胞生成白细胞介素6的研究[J].1997,(12).
- [2]A E, Simpson,P T, Tomkins,K L, Cooper.An investigation of the temporal induction of cytokine mRNAs in LPS-challenged thioglycollate-elicited murine peritoneal macrophages using the reverse transcription polymerase chain reaction.[J].1997,46(2).
- [3]Jang, Meishiang,Cai, Lining.Cancer chemopreventive activity of resveratrol, a natural product derived from grapes.[J].1997,275(5297).
- [4]冯永红,许实波.白藜芦醇药理作用研究进展[J].1996,(4).
- [5]H, Tilg,C A, Dinarello,J W, Mier.IL-6 and APPs: anti-inflammatory and immunosuppressive mediators.[J].1997,18(9).
- [6]中国医学科学院药物研究所编著.中草药现代研究.第三卷[M].1997.
- [7]Paquet, P.,Pierard, G. E..Interleukin-6 and the Skin[J].1996,109(4).
- [8]Mills J,Carroll G,Chapman H,etc.Antagonism of the IL-6 cytokine subfamily--a potential strategy for more effective therapy in rheumatoid arthritis.[J].1998,47(1).
- [9]T, Hirano.Interleukin 6 and its receptor: ten years later.[J].1998,16.
- [10]Gadient RA,Otten UH.Interleukin-6 (IL-6)--a molecule with both beneficial and destructive potentials.[J].1997,52(5).
- [11](美)萨姆布鲁克(Sambrook,J.)等著 金冬雁.分子克隆实验指南[M].1992.
- [12]F, Uenobe,S, Nakamura,M, Miyazawa.Antimutagenic effect of resveratrol against Trp-P-1.[J].1997,373.