You Position: Home > Paper
EFFECTS OF CLAUSENAMIDE ON SYNAPTIC TRANSMISSION OF THE DENTATE GYRUS IN FREELY-MOVING RATS
( views:116, downloads:5 )
- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 5
- DOI:
- 10.3321/j.issn:0513-4870.1999.05.002
- Key Word:
- 黄皮酰胺;突触传递;海马齿状回;自由活动大鼠
Abstract： 目的:研究黄皮酰胺对自由活动大鼠海马齿状回突触传递功能的作用.方法:采用细胞外电生理记录技术.结果:一次性施加HFS能稳定诱导出LTP并维持达5 d;(-)黄皮酰胺(8 mg.kg-1,ig)组PS于连续给药的d 3开始明显增高,至d 5基本达最高值,连续给药7 d后停药,停药后5 d内增高的PS不见明显降低,而测试阈值呈现相反的变化;同剂量的(+)黄皮酰胺对PS和测试阈值无明显影响.结论:(-)黄皮酰胺经口给药也能在大鼠海马组织中达到影响突触传递活动的水平,提示黄皮酰胺对清醒自由活动大鼠海马齿状回突触传递的影响有手性选择性.
- [1]Voronin, L.,Byzov, A.,Kleschevnikov, A.,etc.Neurophysiological analysis of long-term potentiation in mammalian brain[J].1995,66(1).
- [2]S, Maren,M, Baudry.Properties and mechanisms of long-term synaptic plasticity in the mammalian brain: relationships to learning and memory.[J].1995,63(1).
- [3]蒋学英.黄皮酰胺的促智作用机制研究[D].1994.
- [4]G, Buzsáki,Z, Horváth,R, Urioste,etc.High-frequency network oscillation in the hippocampus.[J].1992,256.
- [5]J L, Martinez,B E, Derrick.Long-term potentiation and learning.[J].1996,47.
- [6]Stephen Redman.The Hippocampus, Long-Term Potentiation and Memory[J].1996,23(10‐11).
- [7]刘少林,张均田.（-）,（+）黄皮酰胺对大鼠海马突触传递功能的不同影响[J].1998,(4).