You Position: Home > Paper
EFFECT OF BERBERINE HYDROCHLORIDE ON MUSCARINIC RECEPTORS
( views:181, downloads:33 )
- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 4
- DOI:
- 10.3321/j.issn:0513-4870.1999.04.005
- Key Word:
- 盐酸小檗碱;毒蕈碱受体;乙酰胆碱
Abstract： 目的:研究盐酸小檗碱对乙酰胆碱系统的影响. 方法:采用离体血管环、离体支气管螺旋体及放射配基-受体结合实验等方法.结果:较低浓度的盐酸小檗碱(Ber)对乙酰胆碱的舒张反应有浓度依赖性的增强作用;而较高浓度的Ber可浓度依赖性地直接舒张带内皮的动脉环,此作用在去内皮或阻断M-受体后被完全抑制.在豚鼠离体气管条上,Ber可引起浓度依赖性的收缩反应,而阿托品可阻断这种作用.放射配基-受体结合实验显示盐酸小檗碱可特异性与大鼠脑组织的毒蕈碱受体结合,Ki值为1.6 μmol.L-1.结论:盐酸小檗碱可激动毒蕈碱受体,从而引起血管的内皮依赖性的舒张反应及支气管的收缩.
- [1]P, Bevan.[3H]oxotremorine-M binding to membranes prepared from rat brain and heart: evidence for subtypes of muscarinic receptors.[J].1984,101(1-2).
- [2]P J, Barnes.Muscarinic receptor subtypes in airways.[J].1993,52(5-6).
- [3]J. Hawley,P.C. Rubin,S.J. Hill.Distribution of receptors mediating phosphoinositide hydrolysis in cultured human umbilical artery smooth muscle and endothelial cells[J].1995,49(7).
- [4]Hulme E C,Birdsall N J M,Buckley N J.Muscarinic Receptor Subtypes[J].1990.
- [5]W F, Chiou,M H, Yen,C F, Chen.Mechanism of vasodilatory effect of berberine in rat mesenteric artery.[J].1991,204(1).