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PROTECTION AND ANTI-OXIDATIVE MECHANISM OF 2(3)-TERT-BUTYL-4-HYDROXYANISOLE AGAINST ETHANOL INDUCED GASTRIC LESION IN RATS
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 3
- DOI:
- 10.3321/j.issn:0513-4870.1999.03.003
- Key Word:
- 2(3)叔丁基-4-羟基茴香醚;胃粘膜损伤;胃保护;抗氧化作用
Abstract： 目的:研究叔丁基-4-羟基茴香醚(BHA)对乙醇诱发胃粘膜损伤的保护作用.方法:通过给大鼠ig无水乙醇制备胃粘膜损伤模型,测定胃粘膜内一些酶的活性和MDA含量.结果:ig BHA 20和100 mg.kg-1.d-1连续3 d,能显著防止乙醇诱发的胃粘膜损伤,并降低由乙醇所致的MDA含量增加.BHA有诱导醌还原酶、谷胱甘肽还原酶活性增加的作用,且能阻止由乙醇引起的醌还原酶、谷胱甘肽还原酶和SOD活性的降低.结论:BHA对乙醇诱发大鼠胃粘膜损伤有保护作用,其作用机制可能与BHA诱导抗氧化酶活性增高和抗脂质过氧化作用有关.
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