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THERAPEUTIC EFFECTS OF ESCULENTOSIDE A ON PASSIVE HEYMANN NEPHRITIS IN RATS AND ITS INHIBITION ON CYTOKINE PRODUCTION

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Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
1
DOI:
10.3321/j.issn:0513-4870.1999.01.003
Key Word:
商陆皂苷甲;Heymann肾炎;白细胞介素1;肿瘤坏死因子;白细胞介素6

Abstract: 目的: 商陆皂苷甲(EsA)对大鼠Heymann肾炎(passive Heymann nephritis,PHN)的治疗作用及机理.方法: 大鼠sc Fx1A抗原的抗体制成自身免疫性肾小球肾炎,EsA 5,10和20 mg·kg-1·d-1 ip,连续14 d.结果: EsA可以显著减少肾炎大鼠尿蛋白的产生,电镜和免疫荧光检查发现EsA治疗后肾炎大鼠病理情况明显好转.EsA治疗对血清中炎性细胞因子肿瘤坏死因子(TNF)、白细胞介素1(IL-1)和白细胞介素6(IL-6)的产生具有显著的抑制作用.结论: EsA对大鼠Heymann肾炎具有显著治疗作用,抑制细胞因子产生可能参与EsA抗炎机制.

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