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THE INHIBITORY EFFECT OF ISATIN ON SEIZURE ACTIVITY IN AMYGDALOID KINDLED RATS
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 1
- DOI:
- 10.3321/j.issn:0513-4870.1999.01.001
- Key Word:
- 吲哚醌;单胺氧化酶抑制剂;点燃效应;杏仁核;癫痫
Abstract： 目的:研究吲哚醌对大鼠杏仁核点燃发作的影响及其抗惊厥作用.方法:建立大鼠杏仁核点燃模型,观察发作的电生理指标和行为学变化;在小鼠最大电休克惊厥、戊四唑惊厥和氨基脲惊厥模型计数惊厥发生率.结果: ip吲哚醌50～200 mg·kg-1均可升高杏仁核点燃大鼠的局灶性后放电阈值,降低发作强度和全身性发作 (stage 5) 百分率;可剂量依赖性地对抗小鼠最大电休克发作,并能取消戊四唑惊厥和氨基脲惊厥的强直相,降低戊四唑惊厥的死亡率.结论:吲哚醌对癫痫发作有抑制作用,其机制与抑制MAO-B活性、升高发作阈值有关.
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