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SYNTHESIS AND CYTOTOXICITY OF THE NEW TAXOIDS
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 9
- DOI:
- 10.3321/j.issn:0513-4870.1998.09.005
- Key Word:
- 抗肿瘤活性;紫杉醇
Abstract： Sinenxan A(SIA)为生物合成法得到的新紫杉烷化合物.为寻找有抗肿瘤活性的新型taxol类似物, 对SIA进行结构修饰.设计合成了10个化合物, 在母核中引入四氢呋喃环, 在14β-位或10β-位连接taxol/taxotere侧链, 部分化合物显示一定的抗肿瘤活性.并讨论了这类化合物的构效关系.
- [1]Robert A. Holton,Carmen Somoza,Hyeong Baik Kim,etc.First total synthesis of taxol. 1. Functionalization of the B ring[J].1994,116(4).
- [2]Rick G. Kelsey,Nan C. Vance.Taxol and Cephalomannine Concentrations in the Foliage and Bark of Shade-Grown and Sun-Exposed Taxus brevifolia Trees[J].1992,55(7).
- [3]K C, Nicolaou,Z, Yang,J J, Liu,etc.Total synthesis of taxol.[J].1994,367(6464).