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COMPARISON OF THE CYTOTOXICITY OF FIVE CONSTITUENTS FROM PTERIS SEMIPINNATA L. IN VITRO AND THE ANALYSIS OF THEIR STRUCTURE-ACTIVITY RELATIONSHIPS
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 9
- DOI:
- 10.3321/j.issn:0513-4870.1998.09.001
- Key Word:
- 半边旗;二萜;细胞毒活性;构效关系
Abstract： 用多种人癌细胞株以MTT试验,体外筛选半边旗抗肿瘤活性成分.结果显示:化合物5F,6F,A及半边旗乙醇提取物PSE对5种人癌细胞均有不同程度的杀伤作用,且呈明显的剂量依赖关系.其中6F的活性最强,其次是A,5F,而化合物4F和B对5种细胞均无细胞毒活性.分析它们的构效关系可以推测,α-β-亚甲基环戊酮结构是其活性部位,结构中羟基数目和位置的不同可以影响化合物的活性强度.
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