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FIBRINOLYTIC PROPERTIES AND THROMBOLYTIC EFFECT OF A NOVEL FIBRINOLYTIC ENZYME FROM STREPTOMYCES SP. Y405
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 7
- DOI:
- 10.3321/j.issn:0513-4870.1998.07.001
- Key Word:
- 链霉菌;纤溶酶;溶栓;纤维蛋白原
Abstract： 目的旨在进一步确证纤溶活性的蛋白酶SW-1的溶栓作用和性质.用体外加热平板法、试管凝块法和在体内对大鼠静脉血栓溶解及对纤溶因子的作用等实验, 发现SW-1在体外可直接降解纤维蛋白, 而无激活纤溶酶原的作用. 在体内, SW-1对大鼠静脉血栓有显著的溶解效果, 与同剂量尿激酶的溶栓作用相当. 给药(iv) 30 min后, SW-1引起大鼠血浆中纤溶酶、纤溶酶原水平提高, 纤维蛋白原水平下降, 而对组织型纤溶酶原激活剂(t-PA)、α2-纤溶酶抑制剂无显著影响.提示SW-1是一种具有纤溶活性的蛋白酶,而不是纤溶原激活剂.
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