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TOTAL SYNTHESIS OF SCHIZANDRIN, THE MAIN ACTIVE INGREDIENT ISOLATED FROM THE CHINESE HERBAL MEDICINE FRUCTUS SCHIZANDRAE

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Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
6
DOI:
10.3321/j.issn:0513-4870.1998.06.005
Key Word:
五味子醇甲;非酚氧化偶合;五味子;三氟醋酸铊;全合成

Abstract: 本文以没食子酸为原料进行还原偶合及脱水反应生成顺、反1,4-二(3,4,5-三甲氧基苯基)-2,3-二甲基-2-丁烯化合物(7).将其进行硼氢化反应,然后分别与2,3-二氯-5,6-二氰-1,4-苯醌(DDQ)和三氟醋酸铊(TTFA)在三氟醋酸(TFA)中进行非酚氧化偶合反应合成了中药五味子中活性化学成分五味子醇甲外消旋体,即(αRS)1,2,3,10,11,12-六甲氧基-6,7-二甲基-6-羟基-5,6,7,8-四氢二苯骈[a,c] 环辛烯(9).元素分析,MS,UV,IR及NMR光谱数据均与天然五味子醇甲相符.

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