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EFFECTS OF METHOTREXATE ON EARLY PREGNANCY IN MICE
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 1
- DOI:
- 10.3321/j.issn:0513-4870.1998.01.003
- Key Word:
- 甲氨蝶呤;孕酮;抗早孕
Abstract： 用小鼠抗早孕实验,观察甲氨蝶呤(MTX)单用和合并用药的抗早孕作用.小鼠于妊娠d 7分别一次sc MTX 8,24和72 mg*kg-1可引起胚胎死亡, 妊娠d 13死亡率分别为18.0%,55.5%和60.3%.给药后测定血清孕酮水平,妊娠d 9未发现明显改变,妊娠d 13其水平明显降低.小鼠于妊娠d 7～9注射MTX 24 mg*kg-1连续3d引起胚胎全部死亡.hCG和孕酮可拮抗MTX的抗早孕作用.RU486可增强MTX的抗早孕作用, 提示两药合用抗早孕有协同作用.
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