Relationship between serum procalcitonin,high mobility group box chromoso(m)al protein 1 levels and severity and prognosis of acute pancreatitis

( views:430, downloads:0 )
Author:
ZHANG Wei-jie(Department of Emergency Medicine, Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210008, China)
XU Gui-fang()
TIAN Zhi-qiang()
WU Guo-zhong()
ZOU Xiao-ping()
Journal Title:
Chinese Journal of Pancreatology
Issue:
Volume 12, Issue 05, 2012
DOI:
10.3760/cma.j.issn.1674-1935.2012.05.003
Key Word:
Pancreatitits ; Procalcitonin; High mobility group proteins ; Prognosis

Abstract: Objective To investigate the serum levels of procalcitomn (PCT) and high mobility group box chromosomal protein-1 ( HMGB1 ) in patients with acute pancreatitis (AP) ; and study the relationship between the serum levels of PCT,HMGB1 and the severity and prognosis of AP.Methods The blood samples were collected from 80 AP patients,including 38 severe acute pancreatitis (SAP) patients and 42 mild acute pancreatitis (MAP) patients.The serum levels of HMGB1 were measured by ELISA kit,and the levels of PCT were measured by immunoassay chemiluminescent technique,then their relationship with other biochemical parameters,the severity and prognosis of AP was analyzed.30 healthy adults were treated as the control group.Results The serum PCT and HMGB1 levels were ( 8.18 ± 3.24) μg/L and ( 11.79 ± 3.98 ) μg/L in SAP group,and the corresponding values were (5.67 ± 2.43) μg/L and ( 5.38 ± 2.06) μg/L in MAP group,and both were significantly higher than those in control group [ ( 1.85 ± 0.86) μg/L and ( 1.87 ± 1.47) μg/L,P <0.01 ].The serum level of PCT was positively correlated with serum 1evel of HMGB1 ( r =0.276,P =0.014),and both were positively correlated with Ranson score,APACHE Ⅱ score,Balthazar CT score (P<0.05 or <0.01 ).The HMGB1 levels were significantly higher in patients with organ dysfunction than those in patients without organ dysfunction (P <0.05).Conclusions In AP patients,serum PCT and HMGB1 levels were significantly increased,and they were positively correlated with disease severity.These results suggest that PCT and HMGB1 may act as potential serum markers for AP severity evaluation.

  • [1]Sexton PM,Christopoulos G,Christopoulos A,et al.Procalcitonin has bioactivity at calcitonin receptor family complexes:potential mediator implications in sepsis.Crit Care Med,2008,36:1637-1640.
  • [2]Huang W,Tang Y,Li L.HMGB1,a potent proinflammatory eytokine in sepsis.Cytokine,2010,51:119-126.
  • [3]中华医学会外科学分会胰腺外科学组.重症急性胰腺炎诊治指南.中华外科杂志,2007,45:727-729.
  • [4]Yasuda T,Ueda T,Takeyama Y,et al.Significant increase of serum high-mobility group box chromosomal protein 1 levels in patients with severe acute pancreatitis.Pancreas,2006,33-359-363.
  • [5]Rau BM,Kemppainen EA,Gumbs AA,et al.Early assessment of pancreatic infections and overall prognosis in severe acute pancreatitis by procalcitonin (PCT):a prospective international multicenter study.Ann Surg,2007,245:745-754.
  • [6]Yonetci N,Sungurtekin U,Oruc N,et al.Is procalcitonin a reliable marker for the diagnosis of infected pancreatic necrosis?ANZ J Surg,2004,74:591-595.
  • [7]李红昌,雷若庆,许志伟,等.急性胰腺炎大鼠血和组织中降钙素原水平的变化.中华胰腺病杂志,2010,10,187-189.
  • [8]Qu R,Ji Y,Ling Y,et al.Procalcitonin is a good tool to gride duration of antibiotic therapy in patients with severe acutepancreatitis.A randomized prospective single-center controlled trial.Saudi Med J,2012,33:382-387.
  • [9]Wang H,Bloom O,Zhang M,et al.HMG-1 as a late mediator of endotoxin lethality in mice.Science,1999,285:248-251.
  • [10]Ga(i)ni S,Koldkjaer OG,Mφller HJ,et al.A comparison of highmobility group-boxl protein,lipopolysaccharide-binding protein and procalcitonin in severe community-acquired infections and bacteraemia:a prospective study.Crit Care,2007,11:R76.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn