Clinical application of pancreatic diffusion-weighed imaging at 3T

( views:221, downloads:0 )
Author:
CHEN Shi-yue(Medical Imaging Center, Changhai Hospital, Second Military Medical University, Shanghai 200433, China)
HUANG Wen-cai()
LU Jian-ping(Medical Imaging Center, Changhai Hospital, Second Military Medical University, Shanghai 200433, China)
JIN Ai-guo(Medical Imaging Center, Changhai Hospital, Second Military Medical University, Shanghai 200433, China)
HUANG Jun(Medical Imaging Center, Changhai Hospital, Second Military Medical University, Shanghai 200433, China)
TIAN Bing(Medical Imaging Center, Changhai Hospital, Second Military Medical University, Shanghai 200433, China)
Journal Title:
Chinese Journal of Pancreatology
Issue:
Volume 11, Issue 04, 2011
DOI:
10.3760/cma.j.issn.1674-1935.2011.04.005
Key Word:
Pancreas;Pancreatic neoplasms;Magnetic resonance imaging (MRI);Diffusionweighted imaging (DWI);ADC value

Abstract: Objective To investigate the feasibility of pancreatic DWI at a 3T MR imager and its value for the qualitative diagnosis of pancreatic tumors. Methods For 20 normal healthy volunteers and 47 patients with pancreatic tumors [21 pancreatic carcinoma (PC), 7 mass-forming chronic pancreatitis (MFCP)and 19 cystic lesions), routine pancreatic MRI and pancreatic DWI using b values (500 and 1000 mm2/s)were obtained, the DWI signal intensity (SI) and apparent diffusion coefficient (ADC) value of pancreatic lesions and adjacent tissue was measured. Results In the b = 500 and 1000 mm2/s DWI images, there was no significant difference in ADC value between different parts of normal pancreas. But PC and MFCP were shown as hyperintensity mass, in addition, the related SI1000 of PC at b = 1000 mm2/s DWI was significantly higher than that of MFCP (1.238 +0.448 vs. 0.371 +0.293, P<0. 01). Compared with normal pancreas,beth PC and MFCP presented as decreased ADC500 and ADC1000 value. The ADC1000 of PC was significantly lower than that of MFCP [ ( 1. 087 + 0. 175 ) mm2/s vs. ( 1. 279 ± 0.213 ) mm2/s]. Pancreatic cystic lesions were shown as hyperintensity in DWI at b = 500 mm2/s, but were depicted as iso-intense signal or low-signal lesions in DWI using b = 1000 mm2/s. Both ADC500 and ADC1000 of pancreatic cystic lesions were higher than that of normal pancreas. Conclusions 3T-MR DWI is helpful to differentiate pancreatic lesions. High b value DWI is more valuable for the qualitative diagnosis of pancreatic mass.

  • [1]黄文才.胰腺磁共振扩散加权成像的临床应用进展.中国医学影像技术,2010,26:16-19.
  • [2]Ichikawa T,Haradome H,Hachiya J,et al.Diffusion-weighted MR imaging with a single-shot echoplanar sequence:detection and characterization of focal hepatic lesions.Am J Roentgenol,1998,170:397-402.
  • [3]胡兴荣,陈军.磁共振弥散成像在肝纤维化中的研究进展.世界华人消化杂志,2009,17:288-292.
  • [4]Ichikawa T,Erturk SM,Motosugi U,et al.High-bvalue diffusionweighted MRI in colorectal cancer.Am J Roentgenol,2006,187:181-184.
  • [5]Akisik MF,Aisen AM,Sandrasegaran K,et al.Assessment of chronic pancreatitis:utility of diffusion-weighted MR imaging with secretin enhancement.Radiology,2009,250:103-109.
  • [6]Yamada I,Aung W,Himeno Y,et al.Diffusion coefficients in abdominal organs and hepatic lesions:evaluation with intravoxel incoherent motion ccho-planar MR imaging.Radiology,1999,210:617-623.
  • [7]陈翼,许乙凯,方挺松.MRI多种成像技术在胰腺癌诊断中的价值.中国医学影像技术,2004,20:886-888.
  • [8]任莹,金征宇,冯逢,等.310T磁共振扩散加权成像对胰腺癌的诊断价值初探.中国医学影像技术,2006,22:5812-5831.
  • [9]Fattahi R,Balci NC,Perman WH,et al.Pancreatic diffusionweighted imaging:comparison between mass-forming focal pancreatitis,pancreatic cancer,and normal pancreas.J Magn Resort Imaging,2009,29:350-356.
  • [10]Otsuki M.Chronic pancreatitis:The problems of diagnostic criteria.Pancreatology,2004,4:28-41.
  • [11]Inan N,Arslan A,Akansel G,et al.Diffusion-weighted imaging in the differential diagnosis of cystic lesions of the pancreas.Am J Roentgenol,2008,191:1115-1121.
  • [12]Yoshikawa T,Kawamitsu H,Mitchell DG,et al.ADC Measurement of abdominal organs and sesions using parallel imaging technique.Am J Roentgenol,2006,187:1521-1530.
  • [13]Lee SS,Byun JH,Park B J,et al.Quantitative analysis of diffusionweighted magnetic resonance imaging of the pancreas:usefulness in characterizing solid pancreatic masses.J Magn Reson Imaging,2008,28:928-936.
  • [14]Erturk SM,Ichikawa T,Motosuqi U,et al.Diffusion-weighted MR imaging in the evaluation of pancreatic exocrine function before and after secretin stimulation.Am J Gastroenterol,2006,101:133-136.
  • [15]Tajima Y,Kuroki T,Tsutsumi R,et al.Pancreatic carcinoma coexisting with chronic pancreatitis versus tumor-forming pancreatitis:Diagnostic utility of the time-signal intensity curve from dynamic contrast-enhanced MR imaging.World J Gastroenterol,2007,13:858 -865.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn