Impact of alcohol and smoking on pancreatic calcification in chronic pancreatitis

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Author:
WANG Wei(Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China)
LIAO Zhuan(Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China)
DONG Yuan-hang(Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China)
LI Zhao-shen(Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China)
ZHANG Wen-jun(Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China)
WANG Li-hua(Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China)
ZOU Duo-wu(Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China)
JIN Zhen-dong(Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China)
Journal Title:
CHINESE JOURNAL OF PANCREATOLOGY
Issue:
Volume 10, Issue 05, 2010
DOI:
10.3760/cma.j.issn.1674-1935.2010.05.002
Key Word:
Pancreatitis,chronic;Calcinosis;Smoking;Alcohol drinking

Abstract: Objective To investigate the relationship between alcohol and smoking and the development of pancreatic calcification in chronic pancreatitis (CP) in China. Methods The patients were divided into two groups according to the presence of pancreatic calcification at admission and the data were analyzed; furthermore, the discharged patients without pancreatic calcification were divided into two groups as newly diagnosed pancreatic calcification group and persistent non-pancreatic calcification group. Logistic regression and Cox proportional-hazards model was used for multivariate analysis of the risk factors for pancreatic calcification. Results From January1997 to July 2007, 449 patients with CP were enrolled and followed up successfully. 248 patients presented with pancreatic calcification at admission; among the 201 patients presented without pancreatic calcification, 13 patients developed pancreatic calcification after discharge. Patients with pancreatic calcification had a young age at onset, long CP history, higher incidence of diabetes mellitus and diarrhea. Age at onset ≤ 40, alcohol intake over 20 g/day, and diabetes mellitus and diarrhea were risk factors for pancreatic calcification. The only risk factor of development of pancreatic calcification after discharge was excessive alcohol intake (OR: 3.2). Conclusions Alcohol intake increased the risk of pancreatic calcifications, suggesting the patients abstain from alcohol intake. Further studies are necessary to clarify the role of smoking.

  • [1]Imoto M,DiMagno EP.Cigarette smoking increases the risk of pancreatic calcification in late-onset but not early-onset idiopathic chronic pancreatitis.Pancreas,2000,21:115-119.
  • [2]Talamini G,Bassi C,Falconi M,et al.Alcohol and smoking as risk factors in chronic pancreatitis and pancreatic cancer.Dig Dis Sci,1999,44:1303-1311.
  • [3]Maisonneuve P,Lowenfels AB,Mullhaupt B,et al.Cigarette smoking accelerates progression of alcoholic chronic pancreatitis.Gut,2005,54:510-514.
  • [4]Frulloni L,Scattolini C,Graziani R,et al.Clinical and radiological outcome of patients suffering from chronic pancreatitis associated with gene mutations.Pancreas,2008,37:371-376.
  • [5]Maisonneuve P,Frulloni L,Müllhaupt B,et al.Impact of smoking on patients with idiopathic chronic pancreatitis.Pancreas,2006,33:163-168.
  • [6]Spanier BW,Dijkgraaf MG,Bruno MJ.Epidemiology,aetiology and outcome of acute and chronic pancreatitis:an update.Best Pract Res Clin Gastroenterol,2008,22:45-63.
  • [7]Talamini G,Bassi C,Falconi M,et al.Smoking cessation at the clinical onset of chronic pancreatitis and risk of pancreatic calcifications.Pancreas,2007,35:320-326.
  • [8]Mullhaupt B,Truninger K,Ammann R.Impact of etiology on the painful early stage of chronic pancreatitis:a long-term prospective study.Z Gastroenterol,2005,43:1293-1301.
  • [9]Wittel UA,Hopt UT,Batra SK.Cigarette smoke-induced pancreatic damage:experimental data.Langenbecks Arch Surg,2008,393:581-588.
  • [10]Yadav D,Papachristou GI,Whitcomb DC.Alcohol-associated pancreatitis.Gastroenterol Clin North Am,2007,36:219-238.
  • [11]Cavallini G,Talamini G,Vaona B,et al.Effect of alcohol and smoking on pancreatic lithogenesis in the course of chronic pancreatitis.Pancreas,1994,9:42-46.
  • [12]Massarrat S.Smoking and gut.Arch Iran Med,2008,11:293-305.
  • [13]Pedrazzoli S,Pasquali C,Guzzinati S,et al.Survival rates and cause of death in 174 patients with chronic pancreatitis.J Gastrointest Surg,2008,12:1930-1937.
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