Level and clinical significance of 5-HT and iFABP in severe acute pancreatitis patients with intestinal dysfunction

( views:246, downloads:0 )
Author:
XUE Yu-zheng(Department of Gastroenterology, Third Hospital of Wuxi, Wuxi 214041, China)
LIU Zong-liang(Department of Gastroenterology, Third Hospital of Wuxi, Wuxi 214041, China)
YU Xian-min(Department of Gastroenterology, Third Hospital of Wuxi, Wuxi 214041, China)
LU Yu-feng(Department of Gastroenterology, Third Hospital of Wuxi, Wuxi 214041, China)
DAI Hong(Department of Gastroenterology, Third Hospital of Wuxi, Wuxi 214041, China)
YIN Qun(Department of Gastroenterology, Third Hospital of Wuxi, Wuxi 214041, China)
LI Jian-ping(Department of Gastroenterology, Third Hospital of Wuxi, Wuxi 214041, China)
Journal Title:
CHINESE JOURNAL OF PANCREATOLOGY
Issue:
Volume 10, Issue 02, 2010
DOI:
10.3760/cma.j.issn.1674-1935.2010.02.004
Key Word:
Pancreatitis, acute necrotizing;5-hydroxytryptamine;Fatty acid-binding proteins;Intestinal dysfunction

Abstract: Objective To determine the level and clinical significance of 5-hydroxytryptamine (5-HT) and intestinal fatty acid binding protein (iFABP) in patients of severe acute pancreatitis (SAP) with intestinal dysfunction. Methods The serum and urine in 42 cases of SAP with intestinal dysfunction were collected at day 1, 3 and 7 after admission, respectively. The numbers of bowel sounds were recorded. 20 health subjects were selected as the control. Results The numbers of bowel sounds in health subjects were 5.6 ± 2.3/min. The numbers of bowel sounds in SAP patients at day 1,3 and 7 were 2.3 ± 0.7/min, 1.7 ± 0.2/min and 3.1 ± 1.1/min, respectively;which were significantly lower than that in the control group (P < 0.01). The level of 5-HT in the control group was(86.7 ± 9.5)ng/ml, while the levels of 5-HT in the SAP patients at day 1, 3 and 7 were (112.0 ± 17.8) ng/ml, (130.5 ± 19.7) ng/ml, (107.9 ± 16.3) ng/ml. The level of urine iFABP in the control group was (90.5 ± 19.8) pg/ml, while the levels of urine iFABP in the SAP patients were (1250.2 ± 425.3) pg/ml, (1586.9 ± 523.4) pg/ml, (1154.6 ± 394.0) pg/ml. The levels of 5-HT and urine iFABP in the SAP patients all were significantly higher than those in the control group (P <0.01). The levels of 5-HT and urine iFABP in the SAP patients at day 3 were significantly higher than those in the day 1 and day 7, while there was no significant difference between the two groups. Conclusions Determination of serum 5-HT and urine iFABP in patients with early SAP could effectively evaluate the intestinal function, and it may have potential clinical significance.

  • [1]Frossard JL,Steer ML,Pastor CM.Acute pancreatitis.Lancet,2008,371:143-152.
  • [2]Cappell MS.Acute pancreatitis:etiology,clinical presentation,diagnosis and therapy.Med Clin North Am,2008,92:889-923.
  • [3]Gershon MD.5-HT(serotonin) physiology and related drugs.Curr Opin Gastroenterol,2000,16:113-120.
  • [4]Wade PR,Tamir H,Kirchgessner AL,et al.Analysis of the role of 5-HT in the enteric nervous system using anti-idiotopic antibodies to 5-HT receptors,Am J Physiol,1994,266:G403-G416.
  • [5]Rahman SH,Ammori BJ,Holmfield J,et al.Intestinal hypoperfusion contributes to gut barrier failure in severe acute pancreatitis.J Gastrointest Surg,2003,7:26-35.
  • [6]Kinnala PJ,Kuttila KT,Gronroos JM,et al.Splanchnic and pancreatic tissue perfusion in experimental acute pancreatitis.Stand J Gastroenterol,2002,37:845-849.
  • [7]Connor JD,Rasheed H,Gilani AH,et al.Second messengers in platelet aggregation evoked by serotonin and A23187,a calcium ionophore.Life Sci,2001,69:2759-2764.
  • [8]De Clerck F,Somers Y,Mannaert E,et al.In vitro effects of risperidone and 9-hydroxy-risperidone on human platelet function,plasma coagulation,and fibrinolysis.Clin Ther,2004,26:1261-1273.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn