Vascular epidermis growth factor as a surrogate to evaluate the therapeutic efficacy of pancreatic cancer treated by gamma rays

( views:195, downloads:0 )
Author:
ZHOU Guo-zhong(Department of Gastroenterology, 411 Hospital of PLA, Shanghai 200081,China)
LV Jiao(Department of Gastroenterology, 411 Hospital of PLA, Shanghai 200081,China)
SHI Yun-xing(Department of Gastroenterology, 411 Hospital of PLA, Shanghai 200081,China)
LI Yong-ping(Department of Gastroenterology, 411 Hospital of PLA, Shanghai 200081,China)
ZHENG Zhi-wu(Department of Gastroenterology, 411 Hospital of PLA, Shanghai 200081,China)
LIU Chang-yun(Department of Gastroenterology, 411 Hospital of PLA, Shanghai 200081,China)
JIN Guan-qiu(Department of Gastroenterology, 411 Hospital of PLA, Shanghai 200081,China)
Journal Title:
CHINESE JOURNAL OF PANCREATOLOGY
Issue:
Volume 8, Issue 02, 2008
DOI:
Key Word:
Pancreatic neoplasms; Radiotherapy; Gamma rays; VEGF

Abstract: Objective To analyze the relationship between the change of serum vascular epidermis growth factor(VEGF) level and curative effect of pancreatic cancer treated by gamma rays, and evaluate it clinical significance. Methods The serum VEGF level of thirty patients with pancreatic cancer treated by gamma rays were determined before and one month after treatment. The relationship between curative effect,survival, life quality and the serum VEGF level was analyzed. Results The serum VEGF level of 30 cases before treatment was (624.1 ± 144.3) pg/ml, whereas one month after treatment it was (279.3 ± 83.4) pg/ml(P <0.01 ). In the 19 patient whose serum VEGF level decreased by more than 50%, CR + PR was gained in 18 patients, improved quality of life in 7 patients, and in the 11 patient whose serum VEGF level decreased by less than 50%, CR + PR in 7 patients, improved quality of life in 1 patient( P = 0.012, P = 0. 028). In 24patients who completed 2 years follow-up, 11 of 15 patients whose serum VEGF level decreased by more than 50% survived more than 1 year, which was higher than that of the patients whose serum VEGF level decreased by less than 50%. Conclusions The serum VEGF level decreased significantly after gamma rays treatment and the extent of decrease could be used as a surrogate to evaluate the therapeutic efficacy.

  • [1]张丽萍,聂青,康静波,等.伽玛刀治疗晚期胰腺癌的临床研究.中国现代医学杂志,2005,15:723-725.
  • [2]Dupuy E,Hainaud P,Villemain A,et al.Tumor angiogenesis and tissue factor expression during hepatocellular carcinoma progression in a transgenic mouse mode.J Hepatol,2003,38:793-802.
  • [3]Tsuzuki Y,Mouta Carreira C,Boekhorn M,et al.Pancreas microenvironment promotes VEGF expression and tumor growth:novel window models for pancreatic tumor mierocirculation.Lab Invest,2001,81:1439-1451.
  • [4]王修身,刘孟忠,张昌卿,等.同期放化疗对食管癌患者血管内皮生长因子表达水平的影响--附43例临床资料分析.癌症,2006,25:1428-1432.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn