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Regulatory effect of MRP-1 gene on metastasis of pancreatic cancer
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PANCREATOLOGY
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1674-1935.2006.02.004
- Key Word:
- 抗原,CD;胰腺肿瘤;基因;肿瘤抑制;肿瘤转移
Abstract： 目的探讨运动相关蛋白-1(MRP-1)基因的表达与胰腺癌转移的关系.方法用原位杂交及免疫组织化学技术对7例正常胰腺组织及22例胰腺癌患者组织中MRP-1 mRNA和蛋白表达进行分析.结果原位杂交分析显示,原发性胰腺癌组织中有14例(63.6%)MRP-1阳性表达,其中10例为中～强阳性表达,明显高于正常组织(3/7,42.9%);在13例有转移的淋巴结及远处器官转移的原发性胰腺癌中,MRP-1 mRNA阳性表达显著低于9例无转移的原发性胰腺癌(P ＜ 0.05),免疫组织化学检测结果也与其一致.结论 MRP-1表达在胰腺癌的抗转移中具有一定的作用.
- [1]Erovic BM,Woegerbauer M,Pammer J,etc.Motility-related protein-1/CD9 expression in head and neck squamous cell carcinoma.[J].2003,25(10).
- [2]X, Guo,H, Friess,H U, Graber,etc.KAI1 expression is up-regulated in early pancreatic cancer and decreased in the presence of metastases.[J].1996,56.
- [3]R, Oren,S, Takahashi,C, Doss,etc.TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins.[J].1990,10.
- [4]B, Gudjonsson.Carcinoma of the pancreas: critical analysis of costs, results of resections, and the need for standardized reporting.[J].1995,181.
- [5]M, Sho,M, Adachi,T, Taki,etc.Transmembrane 4 superfamily as a prognostic factor in pancreatic cancer.[J].1998,79.
- [6]Miyake M..Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility[J].1991.
- [7]T M, Gress,F, Müller-Pillasch,M M, Lerch,etc.Expression and in-situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer.[J].1995,62.
- [8]Jose G. Guillem,Miriam F. Levy,Ling Ling Hsieh,etc.Increased levels of phorbin, c-myc, and ornithine decarboxylase RNAs in human colon cancer[J].1990,3(2).