KAI1 gene inhibits in vivo metastasis of human pancreatic cancer

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XU Jian-Hua()
REN Li-Nan()
SHAO Li-Chun()
GUO Xiao-Zhong()
LIU Min-Pei()
Journal Title:
Volume 6, Issue 01, 2006
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  • [1]Wolff JA,Malone RW,Williams P,et al.Direct gene transfer into mouse muscle in vivo.Science,1990,247:1465-1468.
  • [2]akahashi T,Hirano N,Takahashi T,et al.Immunogene therapy against mouse leukemia using B7 molecules.Cancer Gene Ther,2000,7:144-150.
  • [3]Dong JT,Lamb PW,Rinker-Schaeffer CW,et al.KAI1,a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2.Science,1995,268:884-886.
  • [4]Guo XZ,Friess H,Graber HU,et al.KAI1 expression is up-regulated in early pancreatic cancer and decreased in the presence of metastases.Cancer Res,1996,56:4876-4880.
  • [5]Friess H,Guo XZ,Berberat P,et al.Reduced KAI1 expression in pancreatic cancer is associated with lymph node and distant metastases.Int J Cancer,1998,79:349-355.
  • [6]郭晓钟,徐建华,刘民培,等.KAI1基因抑制胰腺癌细胞转移机制的探讨.中华内科杂志,2004,43:360-362.
  • [7]Takaoka A,Hinoda Y,Sato S,et al.Reduced invasive and metastatic potentials of KAI1-transfected melanoma cells.Jpn.J Cancer Res,1998,89:397-404.
  • [8]Takaoka A,Hinoda Y,Satoh S,et al.Suppression of invasive properties of colon cancer cells by a metastasis suppressor KAI1 gene.Oncogene,1998,16:1443-1453.
  • [9]Yang X,Wei LL,Tang C,et al.Overexpression of KAI1 suppresses in vitro invasiveness and in vivo metastasis in breast cancer cells.Cancer Res,2001,61:5284-5288.
  • [10]任丽楠,徐建华,郭晓钟,等.胰腺癌动物模型的建立及意义.胰腺病学,2004,4:109.
  • [11]Kauffman EC,Robinson VL,Stadler WM,et al.Metastasis suppression:the evolving role of metastasis suppressor genes for regulating cancer cell growth at the secondary site.J Urol,2003,169:1122-1133.
  • [12]徐建华,郭晓钟,任丽楠,等.KAI1基因抗胰腺癌细胞转移的研究.中华消化杂志,2004,24:541-543.
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