Abstract: Individualized treatment refers to the clinician's optimal clinical practice for individual patient which directed under modern medical theory and guideline in view of evidence-based medicine,and applied by combined rational and experiential thinking.The medical treatment with combined standardization and individualization is an ideal situation in medical practice.The article explained dialectical relationship between guideline and individualization,and discussed on individualized application of fluid resuscitation in patient with septic shock and on the thinking about how improving the guideline to sepsis.