Abstract： Objective To investigate the efficacy and safety of laparoseopic radiofrequeney ablation (LRFA) in the treatment of advanced-stage pancreatic carcinoma.Methods Between April 2008 and May 2011,the clinical efficacy indications were retrospectively analyzed in 21 patients with advancedstage pancreatic carcinoma after LRFA treatment.Verbalratingscales (VRS) was used to evaluate the alleviation degree of pain.The postoperative serum total bilirubin was detected at day 1 and day 7 and postoperative CA19-9 level at day 7 and day 30.Moreover,the vital signs (such as body temperature),complications,peritoneal drainage,serum amylase and abdominal symptom were observed.B ultrasound were used to reexamine the recurrence of tumor after surgery.A following-up was done in patients in order to observe the postoperative survival period.Results The pain after surgery was alleviated in all the patients to different degrees as compared with that before surgery (preoperation 0～1:n=2; 2～3:n=19 vs postoperation 0～ 1:n=17 ; 2～3:n=4) (P＜0.05).Both serun total bilirubin and CA 19- 9 were significantly decreased after surgery,with total bilirubin (103.23±22.34)μmol/L at day 7 and CA19-9 (170.71±95.64) U/ml at day 30 after surgery (all P＜0.05 ).After surgery,the body temperatures were briefly elevated in patients,which were all decreased to normal after treatment.The peritoneal drainage liquid was most at day 1 after surgery (ranging from 10～180 ml) but gradually rcduced at day 3.Eight patients were found transient increase of serum amylase at day 1 after surgery,with serum amylase( 121.52±62.96)U/ml at day 7 after surgery,whose amylase preoperation was (110.80 ± 51.85) U/ml (P＜0.05).No complication was found,such as intraperitoneal bleeding,abdominal abscess,gastrointestinal burning perforation,bilc lcakage and mesenteric venous thrombosis.The B ultrasound showcd thc total ablation in 15 cases and residual lesions in 6 cases.Mcan survival period was (11±3) months.Conclusion LRFA can effectively improve the pain,yellowness removal,with advantages of mini-invasion and safety.