Abstract： Objective To study the effects of of Heligmosomoides polygyrus on CD4+ T cell secretion and infiltration in T cell-mediated enteritis mice model.Methods OVA-specific CD4+ helper T cells(Th)were transferred into SCID mice to establish the mice model of enteritis for experiment.The mice were randomized into the Heligmosomoides polygyrus-infected group and non-infected group.On days 3,5,7and 14,the mice Were sacrificed in batches.The histopathology change of the colon inflammatory on day 14was studied,and the expressions of IFN-γ,IL-4 and TNF-α on day 14 were examined by real-time fluorescence quantitative PCR.Immunofluorescent staining wag used to measure the number of CD4+ T cells in colonic tissue on days 3,5,7 and 14.Results Compared with the non-infected group,the Heligmosomoides polygyrus-infected mice showed significantly more severe colonic lesions with higher pathological score(5.41±0.53 vs 2.12±0.69,P＜0.05),higher expression levels of IL-4 and TNF-α(IL-4:10.70±4.85 vs 1.00±1.07,TNF-α:6.54+2.88 vs 1.00±0.48,all P＜0.05),but lower expression level of IFN-γ (0.21±0.10 vs 1.00±0.28,P＜0.05).At every time spot,the infected mice had markedly increased number and more intensive infiltration of CD4+ T cells in colonic tissues than the non-infected mice.Conclusion Heligmosomoides polygyrus infection in mice model of CD4+T cell-induced enteritis for experiment aggravates the inflammatory response during the early stage, which may be related to enhanced CD4+ T cell infiltration,induced Th2 and suppressed Th1 secretions.