Influence of edaravone on microcirculation in injuried area of cerebral injury SD rats by optical intrinsic signal imaging (OISI) observation

( views:, downloads: )
Author:
ZHOU Qian(Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China)
WANG Yu-cheng()
LAN Chun-na()
ZHANG Ming-ming(Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China)
JIANG Yu-gang(Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China)
HU De-wen()
Journal Title:
CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
Issue:
Volume 15, Issue 03, 2009
DOI:
10.3760/cma.j.issn.1674-1927.2009.03.003
Key Word:
Brain injuries;Free radical scavengers;Microcirculation;Optical imaging;Edaravone

Abstract: p relatively stable situation of cerebral microcirculation in the injured areas of cerebral injury rats to some extent.

  • [1]Yasuoka N,Nakajima W,lshida A,et al.Neuroprotection of cdaravone on hypoxic-ischemic brain injury in neonatal rats.Dev Brain Res,2004,151:129-139.
  • [2]陈应柱,田野,包仕尧,等.依达拉奉对少突胶质细胞缺血性反应的保护作用研究.中风与神经疾病杂志,2007,24:41-43.
  • [3]Patel HC,Menon DK,Tebbs S,et al.Specialist neurocritical care and outcome from head injury.Intensive Care Med,2002,28:547-553.
  • [4]Jaggi JL,Obrist WD,Gennarelli TA,et al.Relationship of early cerebral blood flow and metabolism to outcome in acute head injury.Neurosurg,1990,72:176-182.
  • [5]Dietrich WD,Alonso O,Halley M,et al.Early microvascular and neuronal consequences of traumatic brain injury:a light and electron microscopic study in rats.J Neurotrauma,1994,11:289-301.
  • [6]Torbati D,Jacks AF,Carey ME,et al.Cerebral cardiovascular and respiratory variables after an experimental brain missile wound.J Neurotrauma,1992,9:S143-S155.
  • [7]Robertson CS,Contant CF,Gokaslan ZL,et al.Cerebral blood flow,arteriovenous oxygen difference,and outcome in head injured patients.Neurosurg,1992,77:360-368.
  • [8]Valeev EK.Iurishchev EP,Timershim KI,et al.The microcirculatory bed and the blood theological properties in the acute period of severe craniocerebral trauma.Zh Vopr Neirokhir Im NN Burdenko,1989,3:24-28.
  • [9]Arthur W,John C.Optical imaging based on intrinsic signals.Brain Mapping:The methods.2nd ed,Amsterdam:Elsevier Science,2002:98-140.
  • [10]Takamatsu Y,Watanabe T.Studies on the concentrations of 3-methyl-1 -phenyl-2-pyrazolin -5-one (MCI-186) in dog plasma and cerebral spinal fluid.Jpn Pharmacol Ther,1997,25:S1793-S1797.
  • [11]Tanahashi N,Fukuuchi Y.Treatment of acute ischemic stroke:recent progress.Intern Med,2002,41:337-344.
  • [12]Edaravone acute infarction study group.Effect of a novel free radical scavenger,edaravone (MCI-186),on acute brain infarction:randomized,placebo-controlled,double-blind study at multicenters.Cerebravase Dis,2003,15:222-229.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn