Abstract: Objective To elucidate the inhibitory effect of sodium channel blocker bupivacaine on the hyperalgesia induced by sciatic nerve injury. Methods Chronic compress injury(CCl) model rats were randomly divided into experimental and control group. After sciatic nerve ligation, experimental rats received bupivacaine powder or gel solution around the injury immediately, while control rats did not receive the treatment. Sprouting of dorsal root ganglion (DRG) and behaviour between two groups were compared.Results Sprout number of DRG in experimental group rats decreased obviously and the symptom of hyperalgesia was improved as compared to control rats. Conclusion Administration of bupivacaine following nerve injury immediately in the wound can prevent the sympathetic sprouting and improve the symptoms.