Expression of vascular endothelial growth factor C,it's receptor VEGFR-3 and count of lymph vessel in different parts of gastric cancer
- Author:
- No author available
- Journal Title:
- JOURNAL OF MODERN CLINICAL MEDICAL BIOENGINEERING
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1008-634X.2007.01.004
- Key Word:
- 胃肿瘤;血管内皮生长因子C;血管内皮生长因子受体3;淋巴管;免疫组织化学
Abstract： 目的 观察胃癌原发灶、淋巴结转移灶及癌旁组织中血管内皮生长因子C(VEGF-C)及其受体(VEGFR-3)表达水平和淋巴管(LV)计数,探讨3者的相互关系及其临床病理意义.方法 49例胃癌手术切除原发灶、36例淋巴结转移灶标本和20例癌旁组织常规制作石蜡包埋切片,VEGF-C、VEGFR-3和LV染色方法均为SP免疫组化法.结果 胃癌原发灶组织VEGF-C、VEGFR-3阳性表达率及LV计数明显高于癌旁组织[(61.2%比25.0%,P＜0.01;57.1%比25.0%,P＜0.05;(13.8±5.2)个/HP比(6.8±3.2)个/HP,P＜0.01].胃癌淋巴结转移灶组织VEGF-C、VEGFR-3表达阳性率及LV计数亦明显高于癌旁组织[61.1%比25.0%,P＜0.01;58.3%比25.0%,P＜0.05;(11.2±4.9)个/HP比(6.8±3.2)个/HP,P＜0.01].组织学分级Ⅱ级、侵袭深度T1～T2、无区域淋巴结转移、N1站淋巴结转移及无远处转移胃癌VEGF-C、VEGFR-3表达阳性率及LV计数均明显低于组织学分级Ⅲ～Ⅳ级、侵袭深度T3～T4、区域淋巴结转移、N2～N3站淋巴结转移及远处转移病例(P＜0.05或P＜0.01).VEGF-C、VEGFR-3表达呈高度一致性(P＜0.01).胃癌原发灶及淋巴结转移灶中VEGF-C、VEGFR-3阳性病例LV计数明显高于阴性病例(P＜0.01).结论 VEGF-C、VEGFR-3和LV可能是反映胃癌发生发展、侵袭潜力、转移发生及预后的重要生物学标记物.VEGF-C通过与VEGFR-3结合具有促胃癌淋巴管生成作用.
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