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Effects of angiotensin-( 1-7 ) on serum nitric oxide and myocardial microvascular integrity after reperfused acute myocardial infarction in rabbits

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Author:
No author available
Journal Title:
JOURNAL OF MODERN CLINICAL MEDICAL BIOENGINEERING
Issue:
1
DOI:
10.3760/cma.j.issn.1008-634X.2007.01.003
Key Word:
血管紧张素(1-7);急性心肌梗死;再灌注损伤;一氧化氮

Abstract: 目的 探讨血管紧张素(1-7)[Ang-(1-7)]对急性心肌梗死再灌注血清一氧化氮(NO)水平及心肌微血管完整性的影响.方法 新西兰雄性大白兔30只,随机分成以下3组:假手术组、缺血再灌注(I-R)对照组和Ang-(1-7)治疗组,每组10只.Ang-(1-7)治疗组经置入式微量泵持续颈静脉给予Ang-(1-7)(25 μg·kg-1·h-1)3 d.假手术组和I-R对照组经微量泵只给予等量的生理盐水.每组均在3 d预处理后,冠状动脉左前降支结扎2 h,再灌注2 h.测定缺血前、后和再灌注2 h时血清NO含量及光镜下心肌灶性出血发生率的变化,并采用氯化三苯四唑(TTC)染色观察心肌梗死范围.结果 心肌缺血前Ang-(1-7)治疗组NO已显著升高(P<0.01);心肌缺血后2 h时,各组NO均比缺血前显著降低(P<0.01),但Ang-(1-7)治疗组比I-R对照组显著增高(P<0.01);再灌注2 h后,各组NO均比缺血2 h时进一步降低,但Ang-(1-7)治疗组仍比I-R对照组显著增高(P<0.01).心肌灶性出血发生率在I-R对照组为65.00%,而Ang-(1-7)治疗组为27.50%(P<0.01).心肌梗死面积在I-R对照组为(28.70±5.45)%,而Ang-(1-7)治疗组为(15.46±4.32)%(P<0.01).结论 静脉持续给予Ang-(1-7)能提高急性心肌梗死再灌注时血清NO水平,可保护心肌微血管的完整性.

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