You Position: Home > Paper
The Changes of Myocardial Apoptosis in Post-resuscitation Myocardial Dysfunction Dog from Cardiac Arrest
( views:208, downloads:20 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF MODERN CLINICAL MEDICAL BIOENGINEERING
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1008-634X.2005.02.002
- Key Word:
- 心肺复苏;复苏后心功能不全;凋亡
Abstract： 目的观察犬心跳骤停复苏后心肌细胞凋亡的变化.方法体外电击诱发犬室颤,3min后复苏,12只犬随机分为2组,CPR组,空白对照组,每组6只,采用Swan-Ganz漂浮导管监测复苏前和后6h的CO和PAWP, 6h后取心肌组织,TUNEL法检测心肌组织凋亡的形态学改变.结果两组各血流动力学指标在心跳骤停前无统计学差异,CPR组的MAP在复苏成功即时高于空白对照组,随后开始下降,在复苏后4、6h低于空白对照组.CPR组的PAWP从心跳骤停前的(5.00±1.26)mmHg一直上升,到复苏后达高峰(28.83±4.79)mmHg,各观察点均高于空白对照组,CO在复苏成功后随时间延长而下降,6h降至最低,复苏后各观察点均低于空白对照组.CPR组心肌细胞凋亡指数高于空白对照组.结论电击诱发室颤犬复苏成功后存在着心功能不全和心肌细胞凋亡增加.
- [1]R J, Gazmuri,M H, Weil,J, Bisera,etc.Myocardial dysfunction after successful resuscitation from cardiac arrest.[J].1996,24.
- [2]X L, Ma,S, Kumar,F, Gao,etc.Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion.[J].1999,99.
- [3]Karl B Kern.Postresuscitation myocardial dysfunction[J].2002,20(1).