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The Expression of SCL Gene in Bone Marrow Stromal Cells From Patients with Leukemia and Normal Individuals
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- Author:
- No author available
- Journal Title:
- JOURNAL OF MODERN CLINICAL MEDICAL BIOENGINEERING
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1674-1927.2002.06.005
- Key Word:
- SCL基因;骨髓基质细胞;RT-PCR-ELISA;白血病
Abstract： 目的初步了解干细胞白血病(SCL)基因在白血病和正常骨髓基质细胞中的表达情况.方法通过长期体外培养扩增骨髓基质细胞,运用RT-PCR-ELISA检测SCL基因的表达.结果 SCL表达于绝大多数CML、AML、CLL患者骨髓基质细胞中,部分正常骨髓基质细胞也表达SCL基因.结论 SCL可能与白血病和正常的骨髓基质细胞的造血调控作用有关.
- [1]T, Blake,N, Adya,C H, Kim,etc.Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis.[J].2000,96.
- [2]李扬秋.干细胞白血病基因在白血病中的表达[J].1997,(2).
- [3]罗成基, 裴血涛主编.造血微环境:基础与临床[M].2001.
- [4]Eric Delabesse,Muriel Bernard,ValÉrie Meyer,etc.TAL1 expression does not occur in the majority of T-ALL blasts[J].1998,102(2).