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Study of Lymphocyte Subpopulation in Peripheral Blood and Cerebrospinal Fluid in Patients with Multiple Sclerosis
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- Author:
- No author available
- Journal Title:
- JOURNAL OF MODERN CLINICAL MEDICAL BIOENGINEERING
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1674-1927.2002.02.005
- Key Word:
- 多发性硬化;淋巴细胞亚群;脑脊液;单克隆抗体
Abstract： 目的观察多发性硬化患者外周血及脑脊液中淋巴细胞亚群的水平. 方法用碱性磷酸酶抗磷酸酶法检测了56例多发性硬化(MS)活动期患者外周血和脑脊液(CSF)的淋巴细胞亚群.结果:活动期MS患者外周血CD4+、CD8+细胞较对照组减少,CD25+细胞、CD4+/CD8+比值较对照组升高(p<0.05).CSF中CD4+、CD25+细胞、CD4+/CD8+比值较对照组升高,CD8+细胞降低(p<0.05<0.05),且CSF中淋巴细胞亚群均高于自身外周血中的相应细胞(p<0.05).经肾上腺皮质类固醇激素治疗后,随病情缓解,外周血、CSF中的淋巴细胞亚群均有不同程度的改善. 结论淋巴细胞亚群可能参与MS的发病,并与MS的缓解-复发有关.
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