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Cyclophilin mRNA Expression in Peripheral Mononuclear Cells from Systemic Lupus Erythematosus Patients
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- Author:
- No author available
- Journal Title:
- JOURNAL OF MODERN CLINUICAL MEDICAL bIOENGENEERING
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1674-1927.2001.03.002
- Key Word:
- 系统性红斑狼疮;环孢素A受体;信使RNA
Abstract： 目的探讨静止期、活动期系统性红斑狼疮病人(SLE)外周血单个核细胞(PBMC)环孢素A受体(CyP) mRNA表达及糖皮质激素对其表达的影响,为临床应用环孢素A辅助治疗该病提供理论依据.方法采用逆转录PCR方法,经凝胶图像半定量分析,检测患者外周血单个核细胞CyP mRNA的表达.结果 SLE病人外周血单个核细胞存在有CyP mRNA的表达,静止期较正常人差异无显著性(p>0.05)意义,但在活动期CyP mRNA的表达较正常人和静止期病人明显降低(p<0.01),地塞米松处理后,活动期病人CyP mRNA的表达水平显著上升(p<0.01).结论 SLE病人有CyP mRNA的表达,但活动期明显下降,糖皮质激素可改善CyP mRNA的表达.
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