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Prethrombotic state gene predictions and diagnosis of venous thromboembolism after large traumatic surgery including orthopedic joint replacement and implant placement

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Author:: No author available

Journal Title:: JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH

Issue:: 26

DOI:: 10.3969/j.issn.1673-8225.2012.26.029

Key Word:: 深静脉血栓;骨科术后;静脉血栓形成;肺栓塞;基因;诊断;人工关节;植入体

Abstract：背景:目前创伤或骨科手术后的静脉血栓栓塞症早期基因诊断日益受到重视.目的:综述目前用于预测诊断骨科术后静脉血栓栓塞症较为成熟的一些基因的研究进展.方法:通过网络检索CNKI和PubMed数据库等2000-01/2011-01关于骨科术后静脉血栓基因诊断的文章,在标题和摘要中以"静脉血栓形成,深静脉血栓,肺栓塞,基因,诊断"或"thrombosis;DVT;PE;gene"为关键词.结果与结论:近年来临床和基础研究证实,骨科术后的静脉血栓栓塞症是人类典型的多基因遗传性疾病,至今发现了一些和血液高凝有关的突变基因与静脉血栓形成有密切关系,分别是:凝血因子V,抗凝血酶Ⅲ,蛋白C,蛋白S,纤溶酶原,纤维蛋白原,肝素辅因子Ⅱ,血栓调节蛋白和凝血因子Ⅻ.了解骨科术后静脉血栓栓塞症的遗传性致病基因机制,有利于早诊断、早治疗,降低其危害.

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