Abstract： Objective To observe the effect of comprehensive nursing intervention on preventing orthostatic hypotension(OH) in the elderly.Methods Questionnaire was used to interview 334 elderly men,who were classified into groups with and without OH,and general and clinical situation were compared.Comprehensive nursing intervention and follow-up were carried out on 97 OH patients,the awareness rate of OH,the frequency of orthostatic hypotension measurement and the incidence rate of symptoms were compared before and after the intervention.Results The differences of BMI,waist-hip ratio,standing heart rate,CHO,TG,LDL-C,HDL-C and blood sugar level between two groups were not statistically significant (P ＞ 0.05).Compared to the patients without OH,OH patients were older,their lying heart rate was slower,lying blood pressure was higher,standing blood pressure was lower and creatinine was higher.In the meantime,the incidence rate of high blood pressure,coronary heart disease and stroke of patients with OH was obviously higher than that of the patients without OH,and the difference was statistically significant (P ＜ 0.05).The OH patients' awareness of OH and frequency of orthostatic hypotension measurement were 81.4％ and 47.4％ after the intervention,much higher than those betore the intervention (3.1％ and 5.2％),and the differences were statistically significant (x2 =122.01,44.72,respectively ;P ＜ 0.01).The incidence rate of symptoms after the intervention was 5.2％,while that before the intervention was 15.5％,and the difference was statistically significant (x2 =5.58,P ＜ 0.05).Conclusions Orthostatic hypotension often occurs in elderly people.Comprehensive nursing intervention measures can improve the rate of awareness and reduce the incidence of symptoms of patients with orthostatic hypotension.