Abstract: Objective To investigate the quality of life and metal stress of breast cancer patients'spouses in the perioperative period,and analyze the relationship between them.Methods Self-made General Information Questionnaire (WHOQOL-BREF) aud relative stress scale (RSS) were used to investigate 110 breast cancer patients' spouses during the perioperative period,in order to analyze the relationship betweeu quality of life and metal stress.Results A total of 110 copies of questionnaires were gave out,102 valid questionnaires,effective recovery was 92.73%.The scores of quality of life in physiology,psychology,social relationship and environment were (13.34 ± 1.88),(13.95 ± 2.63),(13.61 ± 2.45) and (12.22 ± 2.47)respectively and the score of RSS was (11.16 ±4.69).There was a negative correlation between the scores of WHOQOL-BREF and the RSS,the metal suffering as well as the confusion of life (P < 0.05).Only the scores of psychology and social relationship were negatively related to the negative emotions because of the patients (P < 0.05).Conclusions The quality of life of breast cancer patients' spouses during perioperative period is negatively affected by their metal stress.