Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer
- Author:
- No author available
- Journal Title:
- World Journal of Gastroenterology
- Issue:
- 22
- DOI:
- 10.3748/wjg.v18.i22.2827
- Key Word:
- Association study;Colorectal cancer;MicroRNA;Single nucleotide polymorphism
Abstract： AIM:To investigate whether selected single nucleotide polymorphisms (SNPs) in miR-196a2,miR-27a and miR146a genes are associated with sporadic colorectal cancer (CRC).METHODS:In order to investigate the effect of these SNPs in CRC,we performed a case-control study of 197 cases of sporadic CRC and 212 cancer-free controls originating from the Central-European Caucasian population using TaqMan Real-Time polymerase chain reaction and allelic discrimination analysis.RESULTS:The genotype and allele frequencies of SNPs were compared between the cases and the controis.None of the performed analysis showed any statistically significant results.CONCLUSION:Our data suggest a lack of association between rs11614913,rs895819 and rs2910164 and colorectal cancer risk in the Central-European Caucasian population,a population with an extremely high incidence of sporadic colorectal cancer.
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