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Simple and reproducible hepatectomy in the mouse using the clip technique

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Author:
No author available
Journal Title:
World Journal of Gastroenterology
Issue:
22
DOI:
10.3748/wjg.v18.i22.2767
Key Word:
Hepatectomy;Animal model;Clip;Microsurgery;Surgical technique

Abstract: AIM:TO investigate the reliability of massive hepatectomy models by using clip techniques.METHODS:We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%.The impact of various factors in the different models was also analyzed,including learning curves,operative time,survival curves,and histopathological findings.RESULTS:According to anatomical results,models with 75%,80%,and 90% hepatectomy produced massive hepatectomy.Learning curves and operative times were most optimal with the clip technique.Each hepatectomy performed using the clip technique produced a reasonable survival curve,and there were no differences in histopathological findings between the suture and clip techniques.CONCLUSION:Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data.

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