Abstract: AIM:TO investigate the reliability of massive hepatectomy models by using clip techniques.METHODS:We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%.The impact of various factors in the different models was also analyzed,including learning curves,operative time,survival curves,and histopathological findings.RESULTS:According to anatomical results,models with 75%,80%,and 90% hepatectomy produced massive hepatectomy.Learning curves and operative times were most optimal with the clip technique.Each hepatectomy performed using the clip technique produced a reasonable survival curve,and there were no differences in histopathological findings between the suture and clip techniques.CONCLUSION:Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data.