Triterpene Acids from Toddalia asiatica

( views:1325, downloads:0 )
HUANG Ping()
Karagianis Gloria()
WEI Shan-xin()
Journal Title:
Volume 17, Issue 04, 2005
Key Word:
Toddalia asiatica;Rutaceae;triterpene acid

Abstract: Four new triterpene acids,2α,3α, 19α-trihydroxy-11-oxo-urs-12-en-28-oic acid(1) ,2α,3α, 11α, 19α-tetrahydroxy-urs12-en-28-oic acid(2), 2α, 3α-dihydroxy-19-oxo-18, 19-seco-urs-11, 13 ( 18)-dien-28-oic acid(3) and 2α, 3β, 19α-trihydroxyolean-11, 13( 18)-dien-28-olic acid(4)were isolated from the stem of Toddalia asiatica, along with the known compounds euscaphic acid (5), arjunic acid(6), toddaculin, toddalolactone and β-sitosterol. Their structures were elucidated on the basis of spectral evidence.

  • [1]Hao XY,Peng L, Ye L, et al. A study on anti-inflammatory and analgesic effects of alkaloids of Toddalia asiatica. Journal of Chinese Integrative Medicine, 2004,2: 450-452
  • [2]Guo S, Li S, Peng Z, et al. Isolation and identification of active constituent of Toddalia asiatica in cardiovascular system. Journal of Chinese Medical Material, 1998,21:515-516
  • [3]Tsai IL, Wun MF, Teng CM, et al. Anti-platelet aggregation constituents from Formosan Toddalia asiatica. Phytochemistry ,1998,48:1377-1382
  • [4]Ishii H, Tan S, Wang JP, et al. Studies on the chemical constituents of rutaceous plants. LXVII. The chemical constituents of Toddalia asiatica ( L. ) Lam. ( T. aculeata Pers). Examination of coumarins using supercritical fluid and soxhlet extraction. Is toddalolactone a genuine natural coumarin? Yakugaku Zasshi, 1991,111 (7): 376-385
  • [5]Ishii H, Kobayashi J, Ishikawa M, et al. Studies on the chemical constituents of Rutaceae plants. LXVI. The chemical constituents of Toddalia asiatica ( L. ) Lam. ( T. aculeata Pers. ).( 1 ). Chemical constituents of the root bark. Yakugaku Zasshi,1991,111 (7) :365-375
  • [6]Fang JM, Wang KC, Cheng YS. Steroids and triterpenoids from Rosa laevigata . Ph ytochemistry , 1991,30: 3383-3387
  • [7]Zhao WQ, Ding LS, Zhang Q, et al. A novel ursane triterpene from Rubus swinhoei. Chin Chem Left,2001,12:245-246
  • [8]Kakuno T,Yoshikawa K, Arihara S. Ilexosides A,B,C and D,anti-allergic 18, 19-seco-ursane glycosides from fruit of Ilex crenata. Terahedron Letters, 1991,32:3535-3538
  • [9]Kakuno T, Yoshikawa K,Arihara S, et al. Ilexosides E,F,G,H and I, Novel 18, 19-seco-ursane glycosides from fruit of Ilex crenata. Tetrahedron , 1991,47: 7219-7226
  • [10]Begum S, Farhat F,Siddiqui BS.Triterpenoids from the leaves of Eucalyptus camaldulensis var. obtusa. J Nat Prod, 1997,60:20-23
  • [11]Seto T,Tanaka T,Tanka O, et al.β-Glucosyl esters of 19α-hydroxyursolic acid derivatives in leaves of Rubus species. Phyto chemistry, 1984,23 :2829-2834
  • [12]Cheng DL, Cao XP. Pomolic acid derivatives from the root of Sanguisorba officnalis . Phytochemistry , 1992,31:1317-1320
  • [13]Delgado MCC, Silva MS, Fo RB. 3β-Hydroxy-21β- E-cinnamoyl oxyolean-12-en-28-oic acid, a tritepenoid from Enterolobium contorsiliquum . Phtochemistry , 1984,23: 2289-2292
  • [14]De Rosa S, Iodice C, Mitova M, et al. Triterpene saponins and iridoid glucosides from Galium rivale. Phytochemistry, 2000,54:751-756
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615