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Function of intersectin in endocytosis and exocytosis

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 4

DOI:: No doi available

Key Word:: intersectin;胞吞;胞吐;网格蛋白

Abstract： Intersectin是一种进化上高度保守的多功能衔接蛋白/支架蛋白,具有多个功能结构域.这些结构域能够与胞吞和胞吐相关蛋白,如介导突触囊泡循环的网格蛋白、与细胞质膜微囊内吞相关的蛋白、与调控肾离子运输相关的无赖氨酸激酶以及介导胞吐过程的Cdc42等发生作用.近年来,人们对intersectin在唐氏综合症(Down syndrome,DS)、阿尔茨海默病(Alzheimer disease,AD)等众多神经退行性疾病以及内分泌组织肿瘤中的作用进行了广泛研究.本文综述了intersectin结构特征、在胞吞和胞吐中的功能及其与相关疾病方面的研究进展.

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