Amino acids 395-416 in DNA binding domain of STAT4 is involved in IL-12-induced nuclear import of STAT4

( views:203, downloads:0 )
HUANG Yu-Mei()
WEN Ya-Ping()
LI Xuan-An()
YUAN Yuan()
LUO Qi-Zhi()
LI Ming()
Journal Title:
Acta Physiologica Sinica
Volume 64, Issue 04, 2012
Key Word:


  • 1.O'Shea JJ,Plenge R.JAK and STAT signaling molecules in immunoregulation and immune-mediated disease,Immunity 2012; 36(4):542-550.
  • 2.Stark GR,Damell JE Jr.The JAK-STAT pathway at twenty.Immunity 2012; 36(4):503-514.
  • 3.Vera J,Rateitschak K,Lange F,Kossow C,Wolkenhauer O,Jaster R.Systems biology of JAK-STAT signalling in human malignancies.Prog Biophys Mol Biol 2011; 106 (2):426-434.
  • 4.Wang YH,Huang ML.Organogenesis and tumorigenesis:insight from the JAK/STAT pathway in the Drosophila eye.Dev Dyn 2010; 239(10):2522-2533.
  • 5.Paine PL,Feldherr CM.Nucleocytoplasmic exchange of macromolecules.Exp Cell Res 1972; 74(1):81-98.
  • 6.Reich NC,Liu L.Tracking STAT nuclear traffic.Nat Rev Immunol 2006; 6(8):602-612.
  • 7.McBride KM,Banninger G,McDonald C,Reich NC.Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha.EMBO J 2002; 21 (7):1754-1763.
  • 8.Fagerlund R,Melen K,Kinnunen L,Julkunen I.Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5.J Biol Chem 2002; 277(33):30072-30078.
  • 9.Melen K,Kinnunen L,Julkunen I.Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs.J Biol Chem 2001; 276(19):16447-16455.
  • 10.Cokol M,Nair R,Rost B.Finding nuclear localization signals.EMBO Rep 2000; 1(5):411-415.
  • 11.Ma J,Zhang T,Novotny-Diermayr V,Tan AL,Cao X.A novel sequence in the coiled-coil domain of Stat3 essential for its nuclear translocation.J Biol Chem 2003; 278(31):29252-29260.
  • 12.Watford WT,Hissong BD,Bream JH,Kanno Y,Muul L,O'Shea JJ.Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4.Immunol Rev 2004; 202:139-156.
  • 13.Wurster AL,Tanaka T,Grusby MJ.The biology of Stat4 and Stat6.Oncogene 2000; 19(21):2577-2584.
  • 14.Horvath CM.STAT proteins and transcriptional responses to extracellular signals.Trends Biochem Sci 2000; 25(10):496-502.
  • 15.Meyer T,Vinkemeier U.Nucleocytoplasmic shuttling of STAT transcription factors.Eur J Biochem 2004; 271(23-24):4606-4612.
  • 16.Zeng R,Aoki Y,Yoshida M,Arai K,Watanabe S.Stat5B shuttles between cytoplasm and nucleus in a cytokine-dependent and in-dependent manner.J Immunol 2002; 168:4567-4575.
  • 17.Toyoda H,Ido M,Hayashi T,Gabazza EC,Suzuki K,Bu J,Tanaka S,Nakano T,Kamiya H,Chipeta J,Kisenge RR,Kang J,Hori H,Komada Y.Impairment of IL-12-dependent STAT4 nuctear translocation in a patient with recurrent Mycobacterium avium infection.J Immunol 2004; 172(6):3905-3912.
  • 18.Matte C,Descoteaux A.Leishmania donovani amastigotes impair gamma interferon-induced STATlalpha nuclear translocation by blocking the interaction between STATlalpha and importin-alpha5.Infect Immun 2010; 78(9):3736-3743.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615