Facilitation of synaptic transmission and connections of entorhinal-hippocampal pathway by 5-HT2C receptor subtype: multi-electrode array recordings

( views:75, downloads:0 )
XU Yan()
JIN Jian-Hui()
WANG Yan()
WANG Rui-Rui()
LI Zhen()
CHEN Jun()
Journal Title:
Acta Physiologica Sinica
Volume 64, Issue 03, 2012
Key Word:


  • 1.Clemett DA.,Punhani T,Duxon MS,Blackburn TP,Fone KC.Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS.Neuropharmacology 2000;39(1):123-132.
  • 2.Martin JR,Bos M,Jenck F,Moreau J,Mutel V,Sleight AJ,Wichmann J,Andrews JS,Berendsen HH,Broekkamp CL,Ruigt GS,Kohler C,Delft AM.5-HT2C receptor agonists:pharmacological characteristics and therapeutic potential.J Pharmacol Exp Ther 1998; 286(2):913-924.
  • 3.Siuciak JA,Chapin DS,McCarthy SA,Guanowsky V,Brown J,Chiang P,Marala R,Patterson T,Seymour PA,Swick A,Iredale PA.CP-809,101,a selective 5-HT2C agonist,shows activity in animal models of antipsychotic activity.Neuropharmacology 2007; 52(2):279-290.
  • 4.Dunlop J,Sabb AL,Mazandarani H,Zhang J,Kalgaonker S,Shukhina E,Sukoff S,Vogel RL,Stack G,Schechter L,Harrison BL,Rosenzweig-Lipson S.WAY-163909[(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1h i]indole],a novel 5-hydroxy-tryptamine 2C receptor-selective agonist with anorectic activity.J Pharmacol Exp Ther 2005; 313(2):862-869.
  • 5.Kennett GA,Lightowler S,de Biasi V,Stevens NC,Wood MD,Tulloch IF,Blackburn TP.Effect of chronic administration of selective 5-hydroxytryptamine and noradrenaline uptake inhibitors on a putative index of 5-HT2C/2B receptor function.Neuropharmacology 1994; 33(12):1581-1588.
  • 6.Bagdy G,Graf M,Anheuer ZE,Modos EA,Kantor S.Anxiety-like effects induced by acute fluoxetine,sertraline or m-CPP treatment are reversed by pretreatment with the 5-HT2C receptor antagonist SB-242084 but not the 5-HT1A receptor antagonist WAY-100635.Int J Neuropsychopharmacol 2001; 4(4):399-408.
  • 7.Murphy DL,Mueller EA,Hill JL,Tolliver T J,Jacobsen FM.Comparative anxiogenic,neuroendocrine,and other physiologic effects of m-chlorophenylpiperazine given intravenously or orally to healthy volunteers.Psychopharmacology 1989; 98(2):275-282.
  • 8.Duvernoy HM.The Human Hippocampus.3rd ed.Heidelberg:Springer Press,2005,5-37.
  • 9.Byrne JH,Roberts JL.From Molecules to Networks:An Introduction to Cellular and Molecular Neurosience(导读版).2nd ed.Beijing:Science Press,2010,539-608.
  • 10.Zhao XY,Liu MG,Yuan DL,Wang Y,Zhang FK,Chen XF,Zhang FK,Li H,He XS,Chen J.Nociception-induced spatial and temporal plasticity of synaptic connection and function in the hippocampal formation of rats:a multi-electrode array recording.Mol Pain 2009; 5:55.
  • 11.Liu MG,Wang RR,Chen XF,Zhang FK,Cui XY,Chen J.Differential roles of ERK,JNK and p38 MAPK in painrelated spatial and temporal enhancement of synaptic responses in the hippocampal formation of rats:Multi-electrode array recordings.Brain Res 2011; 1382:57-69.
  • 12.Liu MG,Lu D,Wang Y,Chen XF,Li Z,Xu Y,Jin JH,Wang RR,Chen J.Counteracting roles of metabotropic glutamate receptor subtypes 1 and 5 in regulation of pain-related spatial and temporal synaptic plasticity in rat entorhinal-hippocampal pathways.Neurosci Lett 2012; 507(1):38-42.
  • 13.Ju G(鞠躬).Neuroscience.1st ed.Beijing:People's Medical Publishing House,2004,68-117 (Chinese).
  • 14.Hori Y,Endo K,Takahashi T.Long-lasting synaptic facilitation induced by serotonin in superficial dorsal horn neurones of the rat spinal cord.J Physiol 1996; 492(3):867-876.
  • 15.Regina MJ,Winter JC,Rabin RA.Characterization of a novel effect of serotonin 5-HT1A and 5-HT2A receptors:increasing cGMP levels in rat frontal cortex.Neuropharmacology 2003; 45(8):1041-1049.
  • 16.Oka H,Shimono K,Ogawa R,Sugihara H,Taketani M.A new planar multielectrode array for extracellular recording:application to hippocampal acute slice.J Neurosci Methods 1999; 93(1):61-67.
  • 17.Nicholson C,Llinas R.Real time current-source density analysis using multi-electrode array in cat cerebellum.Brain Res 1975; 100:418-424.
  • 18.Dolorfo CL,Amaral DG.Entorhinal cortex of the rat:topographic organization of the cells of origin of the perforant path projection to the dentate gyrus.J Comp Neurol 1998;398(1):25-48.
  • 19.Witter MP,Griffioen AW,Jorritsma-Byham B,Krijnen JL.Entorhinal projections to the hippocampal.CA1 region in the rat:an underestimated pathway.Neurosci Lett 1988; 85(2):193-198.
  • 20.Morin LP,Meyer-Bernstein EL.The ascending serotonergic system in the hamster:comparison with projections of the dorsal and median raphe nuclei.Neuroscience 1999; 91(1):81-105.
  • 21.Douglas RM,Goddard GV.Long-term potentiation of the perforant path-granule cell synapse in the rat hippocampus.Brain Res 1975; 86:205-215.
  • 22.Ryan BK,Anwyl R,Rowan MJ.5-HT2 receptor-mediated reversal of the inhibition of hippocampal long-term potentiation by acute inescapable stress.Neuropharmacology 2008;55(2):175-182.
  • 23.Chen A,Hough CJ,Li H.Serotonin type Ⅱ receptor activation facilitates synaptic plasticity via N-methyl-D-aspartate-mediated mechanism in the rat basolateral amygdala.Neuroscience 2003; 119(1):53-63.
  • 24.Machacek DW,Garraway SM,Shay BL,Hochman S.Serotonin 5-HT2 receptor activation induces a long-lasting amplification of spinal reflex actions in the rat.J Physiol 2001;537(1):201-207.
  • 25.de Chaffoy de Courcelles D,Leysen JE,de Clerck F,Van Belle H,Janssen PA.Evidence that phospholipid turnover is the signal transducing system coupled to serotonin-S2 receptor sites.J Biol Chem 1985; 260(12):7603-7608.
  • 26.de Chaffoy de Courcelles D,Leysen JE,de Clerck F.The signal transducing system coupled to serotonin-S2 receptors.Experientia 1988; 44(2):131-133.
  • 27.Jensen NH,Cremers TI,Sotty F.Therapeutic ptential of 5-HT2C rceptor lgands.ScientificWorldJournal 2010; 10:1870-1885.
  • 28.Ben-Ari Y,Aniksztejn L,Bregestovski P.Protein kinase C modulation of NMDA currents:An important link for LTP induction.Trends Neurosci 1992; 15(9):333-339.
  • 29.Blank T,Zwart R,Nijholt I,Spiess J.Serotonin 5-HT2 receptor activation potentiates N-methyl-D-aspartate receptor-mediated ion currents by a protein kinase C-dependent mechanism.J Neurosci Res 1996; 45(2):153-160.
  • 30.Boothman L,Raley J,Denk F,Hirani E,Sharp T.In vivo evidence that 5-HT2C receptors inhibit 5-HT neuronal activity via a GABAergic mechanism.Br J Pharmacol 2006; 149(7):861-869.
  • 31.Otmakhova NA,Lewey J,Asrican B,Lisman JE.Inhibition of perforant path input to the CA1 region by serotonin and noradrenaline.J Neurophysiol 2005; 94(2):1413-1422.
  • 32.Blitzer RD,Gil O,Landau EM.Cholinergic stimulation enhances long-term potentiation in the CA1 region of rat hippocampus.Neurosci Lett 1990; 119(2):207-210.
  • 33.Drever BD,Riedel G,Platt B.The cholinergic system and hippocampal plasticity.Behav Brain Res 2011; 221 (2):505-514.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn