Cell adhesion molecules in human embryo implantation

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Michiko N.Fukuda(Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, USA,)
Kazuhiro Sugihara(Department of Obstetrics and Gynecology,Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan)
Journal Title:
Acta Physiologica Sinica
Volume 64, Issue 03, 2012
Key Word:
embryonic implantation;gonadotrophin;apoptosis

Abstract: The process of human embryo implantation is mediated not only by evolutionarily conserved mechanisms,but also by a mechanism unique to humans.Evidence suggests that the cell adhesion molecules,L-selectin and trophinin,play a unique role in human embryo implantation.Here,we describe the dual roles of mucin carbohydrate ligand for L-selectin and trophinin protein and ofthe trophinin-associated proteins bystin and tastin.We then describe trophinin-mediated signal transduction in trophectoderm cells and endometrial epithelial cells.This review also covers cadherin and integrin in human embryo implantation.

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