In-vivo and ex-vivo studies on region-specific remodeling of large elastic arteries due to simulated weightlessness and its prevention by gravity-based countermeasure

( views:116, downloads:0 )
GAO Fang()
ZHANG Li-Fan()
CHENG Jiu-Hua()
XUE Jun-Hui()
BAI Yun-Gang()
CHEN Ming-Sheng()
HUANG Wei-Quan()
HUANG Jing()
WU Sheng-Xi()
HAN Hai-Chao()
Journal Title:
Acta Physiologica Sinica
Volume 64, Issue 01, 2012
Key Word:


  • 1.Zhang LF,Yu ZB,Ma J,Mao QW.Peripheral effector mechanism hypothesis of postflight cardiovascular dysfunction.Aviat Space Environ Med 2001; 72:567-575.
  • 2.Zhang LF.Invited review:Vascular adaptation to microgravity:what have we learned? J Appl Physiol 2001; 91:2415-2430.
  • 3.Sides MB,Vernikos J,Convertino VA,Stepanek J,Tripp LD,Draeger J,Hargens AR,Kourtidou-Papadeli C,PavyLeTraon A,Russomano T,Wong JY,Buccello RR,Lee PH,Nangalia V,Saary MJ.The Bellagio report:cardiovascular risks of spaceflight:implications for the future of space travel.Aviat Space Environ Med 2005; 76:877-895.
  • 4. Convertino VA.Status of cardiovascular issues related to spaceflight:implications for future research directions.Respir Physiol Neurobiol 2009; 169 Suppl 1:S34-S37.
  • 5. Convertino VA.Exercise as a countermeasure for physiological adaptation to prolonged space flight.Med Sci Sports Exerc 1996; 28:999-1014.
  • 6. Shipov AA.Artificial gravity.In:Space Biology and Medicine:Humans in Spaceflight.Reston,VA,USA:American Institute of Aeronautics and Astronautics,1996,349-363.
  • 7. Zhang LF (张立藩).Biomedical problems of artificial gravity:Overview and challenge.Space Med Med Eng (航天医学与学工程) 2001; 14(1):70-74 (Chinese,English abstract).
  • 8. Kotovskaia AR.The problem of artificial gravity:the present status and possible approaches.Aviakosm Ekolog Med 2008;42 (6):74-83.
  • 9. Zhang LF.System specificity in responsiveness to intermittent-Gx gravitation during simulated microgravity in rats.J Gravit Physio12005; 12:P1-P4.
  • 10.Hargens AR,Richardson S.Cardiovascular adaptations,fluid shifts,and countermeasure related to space flight.Respir Physiol Neurobio12009; 169 Suppl 1:S30-S33.
  • 11.Morey-Holton ER,Globus RK.Hindlimb unloading rodent model:technical aspects.J Appl Physiol 2002; 92:1367-1377.
  • 12.Lin LJ,Gao F,Bai YG,Bao JX,Huang XF,Ma J,Zhang LF.Contrasting effects of simulated microgravity with and without daily-Gx gravitation on structure and function of cerebral and mesenteric small arteries in rats.J Appl Physiol 2009; 107:1710-1721.
  • 13.Bao JX,Zhang LF,Ma J.Angiotensinogen and AT1R expression in cerebral and femoral arteries during hindlimb unloading in rats.Aviat Space Environ Med 2007; 78:852-858.
  • 14.Sun B,Zhang LF,Gao F,Ma XW,Zhang ML,Liu J,Zhang LN,Ma J.Daily short-period gravitation can prevent functional and structural changes in arteries of simulated microgravity rats.J Appl Physiol 2004; 97:1022-1031.
  • 15.Gao F,Bao JX,Xue JH,Huang J,Huang WQ,Wu SX,Zhang LF.Regional specificity of adaptation change in large elastic arteries of simulated microgravity rats.Acta Physiol Hung 2009; 96(2):167-187.
  • 16.Bardy N,Merval R,Benessiano J,Samuel JL,Tedgui A.Pressure and angiotensin Ⅱ synergistically induce aortic fibronectin expression in organ culture model of rabbit aorta:evidence for a pressure-induced tissue renin-angiotensin system.Circ Res 1996; 79:70-78.
  • 17.Zhang LN,Zhang LF,Ma J.Simulated microgravity enhances vasoconstrictor responsiveness of rat basilar artery.J Appl Physiol 2001; 90:2296-2305.
  • 18.Zhang LF,Sun B,Cao XS,Liu C,Yu ZB,Zhang LN,Cheng JH,Wu YH,Wu XY.Effectiveness of intermittent-Gx gravitation in preventing deconditioning due to simulated microgravity.J Appl Physiol 2003; 95:207-218.
  • 19.Wiener J,Loud AV,Giacomelli F,Anversa P.Morphometric analysis of hypertension-induced hypertrophy of rat thoracic aorta.Am J Pathol 1977; 88:619-634.
  • 20.Huang WQ,Yao B,Sun L,Pu R,Wang L,Zhang R.Immunohistochemical and in situ hybridization studies of gonadotropin releasing hormone (GnRH) and its receptor in rat digestive tract.Life Sci 2001; 68:1727-1734.
  • 21.Meng QJ(孟庆军),Li J,Zhang WH,Zhang LN,Zhang LF.Preparation and indentification of polyclonal antiserum against angiotensinogen.Acta Physiol Sin(生理学报)2003;55(1):11 0-113 (Chinese,English abstract).
  • 22.Huang J,Feng F,Tamamaki N,Tanagawa Y,Obata K,Li YQ,Wu SX.Prenatal and postnatal development of GABAergic neurons in the spinal cord revealed by green fluorescence protein expression in the GAD67-GFP knock-in mouse.Neuroembryol Aging 2007; 4:147-154.
  • 23.Han HC,Ku DN.Contractile responses in arteries subjected to hypertensive pressure in seven-day organ culture.Ann Biomed Eng 2001; 29:467-475.
  • 24.Lehoux S,Tedgui A.Signal transduction of mechanical stresses in the vascular wall..Hypertension 1998; 32:338-345.
  • 25.Watenpaugh DE,Hargens AR.The cardiovascular system in microgravity.In:Fregly MJ,CM Blatteis,eds.Handbook of Physiology:Environmental Physiology.New York:Oxford University Press,1996,631-674.
  • 26.Matsumoto T,Hayashi K.Stress and strain distribution in hypertensive and normotensive rat aorta considering residual strain.J Biomech 1996; 118:62-73.
  • 27.Chuong C J,Fung YC.On residual stresses in arteries.J Biomech Eng 1986; 108:189-192.
  • 28.Shimizu T.Development of the aortic baroreflex system under conditions of microgravity.J Gravit Physiol 1999; 6:P55-P58.
  • 29.Gotoh TM,Nobuhiro F,Kunihiko T,Tomoko M,Shuang G,Hironobu M.Acute hemodynamic responses in the head during microgravity induced by free drop in anesthetized rats.Am J Physiol Regul Integr Comp Physiol 2004; 286:R1063-R1068.
  • 30.Tanaka K,Gotoh TM,Awazu C,Morita H.Regional difference of blood flow in anesthetized rats during reduced gravity induced by parabolic flight.J Appl Physiol 2005; 99:2144-2148.
  • 31.Berk BC.Vascular smooth muscle growth:autocrine growth mechanisms.Physiol Rev 2001; 81:999-1030.
  • 32.Campbell D J,Habener JF.Angiotensinogen gene is expressed and differentially regulated in multiple tissues of the rat.J Clin Invest 1986; 78:31-39.
  • 33.Lehoux S,Tedgui A.Cellular mechanics and gene expression in blood vessels.J Biomechanics 2003; 36:631-643.
  • 34.Wang N,Tytell JD,Ingber DE.Mechanotransduction at a distance:mechanically coupling the extracellular matrix with the nucleus.Nat Rev Mol Cell Biol 2009; 10(1):75-82.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615