Suppressing poly(ADP-ribose)polymerase-1 inhibits tau phosphorylation in HEK293/tau441 cells

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CHEN Qin-Hao()
LIAO Xiao-Mei()
WANG Shao-Hui()
Journal Title:
Acta Physiologica Sinica
Volume 63, Issue 06, 2011
Key Word:


  • 1.Kauppinen TM.Multiple roles for poly(ADP-ribose)polymerase-1 in neurological disease.Neurochem Int 2007;50(7-8):954-958.
  • 2.Liu HP,Lin WY,Wu BT,Liu SH,Wang WF,Tsai CH,Lee CC,Tsai FJ.Evaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer's disease.J Clin Lab Anal 2010; 24(3):182-186.
  • 3.Parihar MS,Hemnani T.Alzheimer's disease pathogenesis and therapeutic interventions.J Clin Neurosci 2004; 11(5):456-467.
  • 4.Ballatore C,Lee VM,Trojanowski JQ.Tau-mediated neurodegeneration in Alzheimer's disease and related disorders.Nat Rev Neurosci 2007; 8(9):663-672.
  • 5.Hanger DP,Anderton BH,Noble W.Tau phosphorylation:the therapeutic challenge for neurodegenerative disease.Trends Mol Med 2009; 15(3):112-119.
  • 6.Songin M,Je(s)ko H,Czapski G,Adamczyk A,Strosznajder RP.GSK-3beta and oxidative stress in aged brain.Role of poly(ADP-ribose)polymerase-1.Folia Neuropathol 2007;45(4):220-229.
  • 7.Love S,Barber R,Wilcock GK.Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease.Brain 1999; 122 (2):247-253.
  • 8.Chen QH(陈钦浩),Wang SH.Relationship between poly(ADP-ribose)polymerase-1 and CNS disease.J Med Mol Biol(医学分子生物学杂志)2010; 7(4):364-367 (Chinese,English abstract).
  • 9.Adamczyk A,Je(s)ko H,Strosznajder RP.Alzheimer's disease related peptides affected cholinergic receptor mediated poly(ADP-ribose)polymerase activity in the hippocampus.Folia Neuropathol 2005; 43(3):139-142.
  • 10.Visochek L,Steingart RA,Vulih-Shultzman 1,Klein R,Priel E,Gozes 1,Cohen-Armon M.PolyADP-ribosylation is involved in neurotrophic activity.J Neurosei 2005; 25(32):7420-7428.
  • 11.Stoothoff WH,Johnson GV.Tau phosphorylation:physiological and pathological consequences.Biochim Biophys Acta 2005; 1739(2-3):280-297.
  • 12.Khatoon S,Grundke-Iqbal I,Iqbal K.Brain levels of microtubule associated protein tau are elevated in Alzheimer's disease brain:a radioimmuno-slot-blot assay for nanograms of the protein.J Neurochem 1992; 59(2):750-753.
  • 13.Reynolds CH,Betts JC,Blackstock WP,Nebreda AR,Anderton BH.Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry:differences in vitro between the mitogen-activated protein kinases ERK2,c-Jun N-terminal kinase and P38,and glycogen synthase kinase-3beta.J Neurochem 2000; 74(4):1587-1595.
  • 14.Buerger K,Zinkowski R,Teipel SJ,Arai H,DeBemardis J,Kerkman D,McCulloch C,Padberg F,Faltraco F,Goernitz A,Tapiola T,Rapoport SI,Pirttil(a) T,M(o)ller H J,Hampel H.Differentiation of geriatric major depression from Alzheimer's disease with CSF tau protein phosphorylated at threonine 231.Am J Psychiatry 2003; 160(2):376-379.
  • 15.Hanger DP,Hughes K,Woodgett JR,Brion JP,Anderton BH.Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau:generation of paired helical filament epitopes and neuronal localisation of the kinase.Neurosci Lett 1992; 147(1):58-62.
  • 16.Rankin CA,Sun Q,Gamblin TC.Pre-assembled tau filaments phosphorylated by GSK-3β form large tangle-like structures.Neurobiol Dis 2008; 31 (3):368-377.
  • 17.Leroy K,Yilmaz Z,Brion JP.Increased level of active GSK3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration.Neuropathol Appl Neurobiol 2007;33(1):43-55.
  • 18.Liu R,Pei JJ,Wang XC,Zhou XW,Tian Q,Winblad B,Wang JZ.Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms.J Neurochem 2005; 94(5):1225-1234.
  • 19.Palfi A,Toth A,Hanto K,Deres P,Szabados E,Szereday Z,Kulcsar G,Kalai T,Hideg K,Gallyas F Jr,Sumegi B,Toth K,Halmosi R.PARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway.J Mol Cell Cardiol 2006; 41(1):149-159.
  • 20.Szanto A,Hellebrand EE,Bognar Z,Tucsek Z,Szabo A,Gallyas F Jr,Sumegi B,Varbiro G.PARP-I inhibitioninduced activation of PI-3-kinase-Akt pathway promotes resistance to taxol.Biochem Pharmacol 2009; 77(8):1348-1357.
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