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Interleukin-1β inhibits the amplitudes of voltage-gated Na+ currents and action potential in cultured cortical neurons of rat

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Author:: No author available

Journal Title:: ACTA PHYSIOLOGICA SINICA

Issue:: 2

DOI:: No doi available

Key Word:: 白介素1β;皮层神经元;电压门控钠电流;动作电位

Abstract：白介素1β(interleukin-1β,IL-1β)是重要的促炎细胞因子,在中枢神经系统的生理学和病理学过程中发挥关键作用.电压门控钠通道是可兴奋细胞电学活动的基础,控制神经元的兴奋性和动作电位.最近的研究又显示了IL-1β与电压门控通道之间的相互作用.为考察中枢神经元中IL-1β与电压门控钠通道之间的相互作用,本研究使用10 ng/mL的IL-1β处理培养的大鼠皮层神经元24 h,通过电压钳技术测定电压门控钠电流,结果表明IL-1β处理抑制钠电流幅度,但不改变其激活和失活性质.与电压钳记录结果相一致,电流钳记录表明IL-1β降低动作电位幅度但不影响阈值.这些结果显示长时间的IL-1β处理可以抑制电压门控钠电流,这种抑制作用减小了动作电位幅度,这町能改变神经元的电学性质、突触传导等基本功能,并提示了IL-1β在神经系统损伤和疾病中作用的新的思路.

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