Paper - WANFANG MED ONLINE

You Position: Home > Paper

"Waste gas is not waste":advance in the research of hydrogen sulfide

( views:51, downloads:0 )

Author:: No author available

Journal Title:: ACTA PHYSIOLOGICA SINICA

Issue:: 6

DOI:: No doi available

Key Word:: 硫化氢;增殖;凋亡;炎症反应;血管新生;离子通道

Abstract：内源性气体信号分子的发现开辟了"废气不废"的新思路.硫化氢(hydrogen sulfide,H1S)是继一氧化氮(nitric oxide,NO)和一氧化碳(carbon monoxide,CO)之后的气体信号分子家系新成员.近年来,人们对H2S的内源性生成、生物学效应及其机制,特别是其在心血管、神经、呼吸、内分泌等系统的疾病发生、发展过程中的病理生理学意义进行了广泛研究.本文综述了近年来H2S相关基础、临床以及药学研究方面的进展,包括H2S对细胞增殖和凋亡、炎症反应、血管新生及离子通道的调节作用,H2S在各种系统疾病发病中的调节作用,H2S供体及其在药学领域的研究进展.

Reference

[1]杨广东,王睿.硫化氢与细胞的增殖和凋亡[J].2007,(2).
[2]赵晶,房立平,许戈阳,等.红细胞内源性硫化氢的测定[J].2007,(5).
[3]CHEN Li,INGRID Sumou,DING Ya-guang,etc.Imbalance of endogenous homocysteine and hydrogen sulfide metabolic pathway in essential hypertensive children[J].2007,(5).
[4]孙宁玲,喜杨,杨松娜,等.新型气体信号分子硫化氢与同型半胱氨酸在高血压患者中的变化探讨[J].2007,(12).
[5]杜军保,陈晓波,耿彬,等.硫化氢作为心血管信号分子的研究[J].2002,(2).
[6]LI Wei,JIN Hong-fang,LIU Die,etc.Hydrogen sulfide induces apoptosis of pulmonary artery smooth muscle cell in rats with pulmonary hypertension induced by high pulmonary blood flow[J].2009,(24).
[7]杜军保,唐朝枢.气体信号分子硫化氢：从基础到临床[J].2008,(32).
[8]Zagli G,Patacchini R,Gensini GF,etc.Hydrogen sulfide inhibits human platelet aggregation.[J].2007,559(1).
[9]Patel HD,Doeller JE,Isbell TS,etc.Hydrogen sulfide mediates the vasoactivity of garlic[J].2007,104(46).
[10]Tang G,Wu L,Wang R.Interaction of hydrogen sulfide with ion channels.[J].2010,37(7).
[11]Guangdong, Yang,Lingyun, Wu,Rui, Wang.Pro-apoptotic effect of endogenous H2S on human aorta smooth muscle cells.[J].2006,20(3).
[12]Grant AD,Ekundi Valentim E,Muscara MN,etc.Differing effects of exogenous and endogenous hydrogen sulphide in carrageenan-induced knee joint synovitis in the rat.[J].2010,159(7).
[13]Bian JS,Choo CH,Tan BH,etc.Effect of hydrogen sulfide on intracellular calcium homeostasis in neuronal cells.[J].2010,56(3).
[14]Yao WZ,Geng B,Chen YH,etc.Serum hydrogen sulfide as a novel marker predicting bacterial involvement in patients with community-acquired lower respiratory tract infections.[J].2009,14(5).
[15]Vitale M,Gobbi G,Micheloni C,etc.Hydrogen sulfide prevents apoptosis of human PMN via inhibition of p38 and caspase 3.[J].2006,86(4).
[16]Tang C,Wei H,Wang Y,etc.Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice.[J].2009,29(2).
[17]Pae HO,Jeon SB,Oh GS,etc.Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide.[J].2006,41(1).
[18]Abe O,Munjal C,Sen U,etc.Hydrogen sulfide regulates homocysteine-mediated glomerulosclerosis.[J].2010,31(5).
[19]Geng B,Tang C,Chen Y,etc.Hydrogen sulfide from adipose tissue is a novel insulin resistance regulator.[J].2009,380(1).
[20]Derwall M,Westerkamp M,Lower C,etc.Hydrogen sulfide does not increase resuscitability in a porcine model of prolonged cardiac arrest.[J].2010,34(2).
[21]Moore PK,Mok YY.Hydrogen sulphide is pro-inflammatory in haemorrhagic shock.[J].2008,57(11).
[22]Hu LF,Lu M,Tiong CX,etc.Neuroprotective effects of hydrogen sulfide on Parkinson's disease rat models.[J].2010,9(2).
[23]Rose P,Whiteman M,Parkinson DB,etc.The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages.[J].2010,12(10).
[24]Han Y,Qin J,Chang X,etc.Hydrogen sulfide and carbon monoxide are in synergy with each other in the pathogenesis of recurrent febrile seizures.[J].2006,26(1).
[25]Robich MP,Feng J,Osipov RM.Effect of hydrogen sulfide in a porcine model of myocardial ischemia-reperfusion: comparison of different administration regimens and characterization of the cellular mechanisms of protection.[J].2009,54(4).
[26]Wang R,Lu Y,Zhang J,etc.The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener.[J].2001,20(21).
[27]McVie R,Bull R,Bocchini JA,etc.Low levels of hydrogen sulfide in the blood of diabetes patients and streptozotocin-treated rats causes vascular inflammation?[J].2010,12(11).
[28]Han Y,Du J,Qin J,etc.Modulating effect of hydrogen sulfide on gamma-aminobutyric acid B receptor in recurrent febrile seizures in rats.[J].2005,53(2).
[29]Wu L,Yang W,Jia X,etc.Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic rats.[J].2009,89(1).
[30]Del Soldato P,Shukla N,Sparatore A,etc.H2S-donating sildenafil (ACS6) inhibits superoxide formation and gp91phox expression in arterial endothelial cells: role of protein kinases A and G.[J].2008,155(7).
[31]Yang G,Wang R,Yang W,etc.H2S, endoplasmic reticulum stress, and apoptosis of insulin-secreting beta cells.[J].2007,282(22).
[32]Cai WJ,Wang MJ,Ding YJ,etc.The hydrogen sulfide donor NaHS promotes angiogenesis in a rat model of hind limb ischemia.[J].2010,12(9).
[33]Pan, SH,Zhao, MY,Kang, K,etc.Role of Hydrogen Sulfide in Hepatic Ischemia-Reperfusion-Induced Injury In Rats[J].2009,15(10).
[34]Hu LF,Bian JS,Wong PT,etc.Hydrogen sulfide protects neurons against hypoxic injury via stimulation of ATP-sensitive potassium channel/protein kinase C/extracellular signal-regulated kinase/heat shock protein 90 pathway.[J].2010,167(2).
[35]Wang WW,Sun YG,Ma SF,etc.Hydrogen sulphide is an inhibitor of L-type calcium channels and mechanical contraction in rat cardiomyocytes.[J].2008,79(4).
[36]Andreas Papapetropoulos,Csaba Szabo,Anastasia Pyriochou.Hydrogen sulfide is an endogenous stimulator of angiogenesis[J].2009,106(51).
[37]Calvert JW,Elston M,Nicholson CK,etc.Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice.[J].2010,122(1).
[38]Ang AD,Cao Y,Moore PK,etc.Mechanism of induction of pancreatic acinar cell apoptosis by hydrogen sulfide.[J].2006,291(3).
[39]Coetzee WA,Lefer DJ,Calvert JW.Novel insights into hydrogen sulfide--mediated cytoprotection.[J].2010,12(10).
[40]Moore PK,Bhatia M,Li L.Hydrogen sulphide--a novel mediator of inflammation?[J].2006,6(2).
[41]Zhu YZ,Huang GY,Zhu YC,etc.Chronic sodium hydrosulfide treatment decreases medial thickening of intramyocardial coronary arterioles, interstitial fibrosis, and ROS production in spontaneously hypertensive rats.[J].2007,293(4).
[42]Osborne NN,Ji D,Fawcett RJ,etc.ACS67, a hydrogen sulfide-releasing derivative of latanoprost acid, attenuates retinal ischemia and oxidative stress to RGC-5 cells in culture.[J].2010,51(1).
[43]Tan CH,Whiteman M,Li L,etc.Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide.[J].2008,117(18).
[44]Bin G,Hui Y,Cheung Y,etc.The possible role of hydrogen sulfide as a smooth muscle cell proliferation inhibitor in rat cultured cells.[J].2004,19(2).
[45]Bhatia M,Moochhala SM,Tamizhselvi R,etc.Pro-inflammatory effects of hydrogen sulphide on substance P in caerulein-induced acute pancreatitis.[J].2008,12(2).
[46]Tang XQ,Shen XT,Huang YE,etc.Hydrogen sulfide antagonizes homocysteine-induced neurotoxicity in PC12 cells.[J].2010,68(3).
[47]Christopher F. Toombs,Edward A. Wintrier,,Michael A. Insko.Detection of exhaled hydrogen sulphide gas in healthy human volunteers during intravenous administration of sodium sulphide[J].2010,69(6).
[48]Huang Y,Li F,He Y,etc.Hydrogen sulfide, a gaseous transmitter, stimulates proliferation of interstitial cells of Cajal via phosphorylation of AKT protein kinase.[J].2010,221(2).