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Hippocampal cAMP response element binding protein and antidepressant treat-ments

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Author:: No author available

Journal Title:: ACTA PHYSIOLOGICA SINICA

Issue:: 6

DOI:: No doi available

Key Word:: cAMP反应元件结合蛋白;海马;抗抑郁药

Abstract：随着对抑郁症发病机制研究的不断深入,当前的重点已从单胺递质调节机制转向抑郁症的病理生理基础研究和抗抑郁治疗的长期作用机制.以脑内cAMP反应元件结合蛋白(cAMP response element binding protein.CREB)为交汇点的细胞内信号转导通路正受到越来越多的关注,尤其是海马CREB的改变.明确海马CERB与抗抑郁治疗的关系,对深入理解抑郁症的病理生理基础和抗抑郁治疗的长期作用机制有重要的意义.因此,本文对近年来海马CREB与抗抑郁治疗的相关研究进行综述,主要涉及CREB的结构和海马内的分布、海马CREB的上游信号通路与抗抑郁治疗、调节海马CREB发挥抗抑郁作用的可能机制.

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