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Effects of amyloid β-protein on hippocampal long-term potentiation

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Author:: No author available

Journal Title:: ACTA PHYSIOLOGICA SINICA

Issue:: 6

DOI:: No doi available

Key Word:: 阿尔茨海默病;β-淀粉样蛋白;长时程增强;海马

Abstract： β-淀粉样蛋白(amyloid β-protein,Aβ)在脑内沉积形成的老年斑是阿尔茨海默病(Alzheimer'S disease,AD)的一个主要病理特征.然而,目前研究表明,在AD出现神经变性前的早期记忆功能障碍中,可溶性AB已经发挥了重要作用.可溶性Aβ引起认知功能下降的机制日前尚不清楚.海马长时程增强(10ng.term potentiation,LTP)是反映突触可塑性的重要指标,被认为与学习和记忆的形成有关.关于Aβ影响海马LTP的研究报道,尤其是利用转基因动物取得的研究成果,为解释AD患者出现的学习记忆功能障碍提供了有力的实验证据.本文结合近年来对AD进行的诸多基础性研究,扼要介绍了Aβ尤其是可溶性Aβ及其活性片段对海马LTP的影响,并讨论了Aβ抑制海马LTP的可能机制.

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