Calpain mediates cardiac troponin Ⅰ degradation in tail-suspended rats

( views:72, downloads:0 )
XU Peng-Tao()
SONG Zhen()
LI Quan()
WANG Yun-Ying()
YU Zhi-Bin()
Journal Title:
Volume 62, Issue 05, 2010
Key Word:


  • [1]Zhang L (张琳),Yu ZB.Regulation of cardiac contractility by phosphorylation and non-phosphorylation of troponin Ⅰ.Prog Physiol Sci (生理科学进展) 2008;39 (1):75-78 (Chinese,English abstract).
  • [2]Yu ZB,Zhang LF,Jin JP.A proteolytic NH2-terminal truncation of cardiac troponin Ⅰ that is up-regulated in simulated microgravity.J Biol Chem 2001;276 (19):15753-15760.
  • [3]Goll DE,Thompson VF,Li H,Wei W,Cong J.The calpain system.Physiol Rev 2003;83 (3):731-801.
  • [4]Barta J,Tóth A,Edes I,Vaszily M,Papp JG,Varró A,Papp Z.Calpain-1-sensitive myofibrillar proteins of the human myocardium.Mol Cell Biochem 2005;278 (1-2):1-8.
  • [5]Ke L,Qi XY,Dijkhuis AJ,Chattier D,Nattel S,Henning RH,Kampinga HH,Brundel BJ.Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation.J Mol Cell Cardiol 2008;45 (5):685-693.
  • [6]Haler G,Viard P,Morel JL,Mironneau J,Mironneau C.Effects of hindlimb suspension on cytosolic Ca2+ and[3H]ryanodine binding in cardiac myocytes.Am J Physiol 1999;276 (4 Pt 2):H1131-H1136.
  • [7]Convettino VA.Status of cardiovascular issues related to space flight:Implications for furore research directions.Respir Physiol Neurobiol 2009;169 Suppl l:S34-S37.
  • [8]Zhang L (张琳),Wang YY,Yu ZB.Depressed responsiveness of cardiomyocytes to isoproterenol in simulated weightlessness rats.Acta Physiol Sin (生理学报) 2007;59 (6):845-850(Chinese,English abstract).
  • [9]Saud ZA,Minobe E,Wang WY,Han DY,Horiuchi M,Hao LY,Kameyama M.Calpastatin binds to a calmodulin-binding site of cardiac Cav1.2 Ca2+ channels.Biochem Biophys Res Commun 2007;364 (2):372-377.
  • [10]Enns DL,Raastad T,Ugelstad I,Belcastro AN.Calpain/calpastatin activities and substrate depletion patterns during hindlimb unweighting and reweighting in skeletal muscle.Eur J Appl Physiol 2007;100 (4):445-455.
  • [11]Mani SK,Balasubramanian S,Zavadzkas JA,Jeffords LB,Rivers WT,Zile MR,Mukherjee R,Spinale FG,Kuppuswamy D.Calpain inhibition preserves myocardial structure and function following myocardial infarction.Am J Physiol Heart Circ Physiol 2009;297 (5):H1744-H1751.
  • [12]Razeghi P,Volpini KC,Wang ME,Youker KA,Stepkowski S,Taegtmeyer H.Mechanical unloading of the heart activates the calpain system.J Mol Cell Cardiol 2007;42 (2):449-452.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615