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Roles of cyclin-dependent kinase 5 in central nervous system development and neurodegenerative diseases

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Author:: No author available

Journal Title:: ACTA PHYSIOLOGICA SINICA

Issue:: 4

DOI:: No doi available

Key Word:: 细胞周期蛋白依赖性蛋白激酶5;p35;p25;突触传递;突触可塑性;神经元存活;神经元死亡;神经退行性疾病

Abstract：脯氨酸引导的丝/苏氨酸蛋白酶--细胞周期蛋白依赖性蛋白激酶5(cyclin-dependent kinase 5,CdkS)是细胞周期素依赖的蛋白酶家族中一个特殊成员.Cdk5不参与细胞周期调控,其活化需要与神经元内广泛表达的激活因子--p35或p39相结合.正常情况下,Cdk5的转录及活性受到体内相关机制的严格调控.在神经系统发育及成熟阶段,Cdk5通过磷酸化细胞骨架蛋白、信号分子以及调节蛋白等众多底物蛋白的特异性丝/苏氨酸位点,在神经元的迁移分化、存活和突触的发生、信息传递、可塑性等诸多方面发挥重要的作用.此外,在一些病理条件下,p35的病理性剪切和Cdk5/p25的形成所导致的Cdk5活性失调及其亚细胞分布改变则促进了神经元的凋亡或死亡,参与了阿尔茨海默氏病(Alzheimer's disease,AD)、帕金森氏病(Parkinson's disease,PD)、亨廷顿氏病(Huntington's disease,HD)以及脊髓侧索硬化症(amyotrophic lateralsclerosis,ALS)等众多神经退行性疾病的发生发展过程.本文综述了Cdk5在中枢神经系统发育和神经退行性疾病中的作用研究方面的进展.

Reference

[1]才晓慧,唐大木,徐如祥.癫痫大鼠海马区中的神经元cdc-2类激酶[J].2001,(3).
[2]Aboitiz F,Montiel J,Lopez J.An hypothesis on the early evolution of the development of the isocortex.[J].2002,57(3/4).
[3]R, Donnellan,R, Chetty.Cyclin E in human cancers.[J].1999,13(8).
[4]L H, Tsai,T, Takahashi,V S, Caviness,etc.Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system.[J].1993,119(4).
[5]Patrick GN,Zhou P,Kwon YT,etc.p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway.[J].1998,273(37).
[6]Armin Heckelp,Frank Gillardonp,Jochen H. Weishaupt,etc.Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction[J].2003,24(2).
[7]J, Lew,R J, Winkfein,H K, Paudel,etc.Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2.[J].1992,267(36).
[8]Wang J,Liu S,Fu Y,etc.Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors.[J].2003,6(10).
[9]Takahashi S,Humbert S,Li E,etc.P35 and P39 are Essential for Cyclin-Dependent Kinase 5 Function During Neurodevelopment.[J].2001,21(17).
[10]Cheng-haung WANG,Wen-ying CHOU,Kung-sheng HUNG,etc.Intrathecal administration of roscovitine inhibits Cdk5 activity and attenuates formalin-induced nociceptive response in rats[J].2005,(1).
[11]Zhang L,Stuenkel EL,Giovannucci DR,etc.Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18.[J].1999,274(7).
[12]Zhang Q.,Zakeri ZF.,Ahuja HS.,etc.Cyclin-Dependent Kinase 5 is Associated with Apoptotic Cell Death During Development and Tissue Remodeling[J].1997,183(2).
[13]Kusakawa G,Ishiguro K,Kishimoto T,etc.Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25.[J].2000,275(22).
[14]Jason Keller,Michael J. ladarola,Ashok B. Kulkarni,etc.Cyclin-dependent kinase 5 activity regulates pain signaling[J].2006,103(3).
[15]Sehwan Park,Uk Namgung,Bo-Hwa Choi,etc.Activation of cyclin-dependent kinase 5 is involved in axonal regeneration[J].2004,25(3).
[16]A, Alvarez,J P, Mu?oz,R B, Maccioni.A Cdk5-p35 stable complex is involved in the beta-amyloid-induced deregulation of Cdk5 activity in hippocampal neurons.[J].2001,264(2).
[17]Moorthamer,M,Zumstein,Mecker-S,Chaudhuri,B.DNA binding protein dbpA binds Cdk5 and inhibits its activity.[J].1999,446(2/3).
[18]Akiko, Asada,Naoyuki, Yamamoto,Masaki, Gohda,etc.Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes.[J].2008,106(3).
[19]Kwon YT,Tsai LH,Crandall JE.Callosal axon guidance defects in p35(-/-) mice.[J].1999,415(2).
[20]I, Delalle,P G, Bhide,V S, Caviness,etc.Temporal and spatial patterns of expression of p35, a regulatory subunit of cyclin-dependent kinase 5, in the nervous system of the mouse.[J].1997,26(5).
[21]O'Hare MJ,Kushwaha N,Vincent I,etc.Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death.[J].2005,25(39).
[22]Herrup K,Gilmore EC.Neocortical cell migration: GABAergic neurons and cells in layers I and VI move in a cyclin-dependent kinase 5-independent manner.[J].2001,21(24).
[23]Patzke H,Tsai LH.Cdk5 sinks into ALS.[J].2002,25(1).
[24]Li BS,Zhang L,Gu J,etc.Integrin alpha(1) beta(1)-mediated activation of cyclin-dependent kinase 5 activity is involved in neurite outgrowth and human neurofilament protein H Lys-Ser-Pro tail domain phosphorylation.[J].2000,20(16).
[25]Vincent I,Bu B,Davies P,etc.Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann-Pick type C murine model.[J].2002,22(15).
[26]Ohshima T,Amin N,Pant H,etc.Neuronal cyclin-dependent kinase 5 activity is critical for survival.[J].2001,21(2).
[27]Ayala R,Morabito M,Niethammer M,etc.NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein.[J].2000,28(3).
[28]Hymie Anisman,Patrice D. Smith,Serge Przedborski,etc.Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease[J].2003,100(23).
[29]Sananbenesi F,Fischer A,Tsai LH,etc.Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory.[J].2005,48(5).
[30]Rashidian J,Iyirhiaro G,Aleyasin H,etc.Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo[J].2005,102(39).
[31]Kriz J,Nguyen MD,Couillard-Despres S,etc.Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1.[J].2003,23(6).
[32]Concha II,Schliebs R,Arendt T,etc.AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576.[J].2002,4(5).
[33]Hamazumi Y,Sato Y,Asada A,etc.Cdk5--p39 is a labile complex with the similar substrate specificity to Cdk5--p35.[J].2007,102(5).
[34]Tseng HC,Gleeson JG,Kulkarni AB,etc.Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration.[J].2004,41(2).
[35]M S, Lee,Y T, Kwon,M, Li,etc.Neurotoxicity induces cleavage of p35 to p25 by calpain.[J].2000,405(6784).
[36]Zhang L,Li BS,Sun MK,etc.Regulation of NMDA receptors by cyclin-dependent kinase-5.[J].2001,98(22).
[37]C, Lambert de Rouvroit,A M, Goffinet.Neuronal migration.[J].2001,105(1-2).
[38]Kelz MB,Chen J,Zeng L,etc.Induction of cyclin-dependent kinase 5 in the hippocampus by chronic electroconvulsive seizures: role of (Delta)FosB.[J].2000,20(24).
[39]J, Lew,K, Beaudette,C M, Litwin,etc.Purification and characterization of a novel proline-directed protein kinase from bovine brain.[J].1992,267(19).
[40]Alejandra Alvarez,Rodrigo Toro,Alfredo Cáceres,etc.Inhibition of tau phosphorylating protein kinase cdk5 prevents β-amyloid-induced neuronal death[J].1999,459(3).
[41]L H, Tsai,I, Delalle,V S, Caviness,etc.P35 is a Neural-Specific Regulatory Subunit of Cyclin-Dependent Kinase 5.[J].1994,371(6496).
[42]Moriwaki A,Li ST,Tomizawa K,etc.Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity.[J].2002,22(7).
[43]M, Nikolic,H, Dudek,Y T, Kwon,etc.The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.[J].1996,10(7).
[44]Chang-Goo Huh,Jerrold M. Ward,Toshio Ohshima.Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death[J].1996,93(20).
[45]M, Zheng,C L, Leung,R K, Liem.Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system.[J].1998,35(2).
[46]Tsai LH,Dhavan R.A decade of CDK5.[J].2001,2(10).
[47]Hallows JL,Chen K,DePinho RA,etc.Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice.[J].2003,23(33).
[48]Vacher C,Luo SQ,Rubinsztein DC,etc.Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity[J].2005,169(4).
[49]Walsh CA,Feng Y.Protein-protein interactions, cytoskeletal regulation and neuronal migration.[J].2001,2(6).
[50]Amin ND,Pant HC,Zheng YL,etc.Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosis.[J].2008,28(14).
[51]Brownlees J,Miller CC,Lau KF,etc.P35/Cdk5 Binds and Phosphorylates Beta-Catenin and Regulates Beta-Catenin/Presenilin-1 Interaction.[J].2001,13(2).
[52]Hisanaga S.,Wei FY.,Saito T.,etc.Brain-derived neurotrophic factor-induced phosphorylation of neurofilament-H subunit in primary cultures of embryo rat cortical neurons[J].2000,113(6).
[53]Rosales JL,Lee KY.Extraneuronal roles of cyclin-dependent kinase 5[J].2006,28(10).
[54]Spiess J,Schrick C,Sananbenesi F,etc.Cyclin-dependent kinase 5 is required for associative learning.[J].2002,22(9).
[55]Kazuyuki Hirooka,Kazuhito Tomizawa,Hideki Matsui,etc.Developmental Alteration of the Expression and Kinase Activity of Cyclin-Dependent Kinase 5 (Cdk5)/p35nck5ain the Rat Retina[J].1996,67(6).
[56]Leise A. Berven,Boris Sarcevic,Orla J. Jupp,etc.Cdk5 is essential for synaptic vesicle endocytosis[J].2003,5(8).
[57]Amin N,Pimenta A,Shea TB,etc.Cdk5 regulates axonal transport and phosphorylation of neurofilaments in cultured neurons.[J].2004,117(Pt.6).
[58]Oo TF,Yarygina O,Rzhetskaya M,etc.Expression of cyclin-dependent kinase 5 and its activator p35 in models of induced apoptotic death in neurons of the substantia nigra in vivo.[J].2001,77(6).
[59]Brandon EP,Gage FH,Dominguez B,etc.Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism.[J].2005,46(4).
[60]Hao C,Song DK,Yong VW,etc.Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2.[J].2006,13(7).
[61]Chen F,Qian L,Yang ZH,etc.Rapsyn interaction with calpain stabilizes AChR clusters at the neuromuscular junction.[J].2007,55(2).
[62]De-Camilli P,Porro EB,Tsai LH,etc.Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2.[J].2001,276(11).
[63]Dhavan R,Areces LB,Tarricone C,etc.Structure and regulation of the CDK5-p25(nck5a) complex.[J].2001,8(3).
[64]Sharma M,Amin ND,Pant HC,etc.Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation.[J].1999,96(20).
[65]Begard S,Bretteville A,Delacourte A,etc.p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death[J].2005,118(6).
[66]Russell P.,Ledee D.,Wang HS.,etc.Cdk5 mediates changes in morphology and promotes apoptosis of astrocytoma cells in response to heat shock[J].2001,114(6).
[67]Cruz JC,Tsai LH.A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease.[J].2004,14(3).
[68]Tseng HC,Goldman JA,Shih H,etc.Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles.[J].2003,40(3).
[69]Liu J,Crandall JE,Morabito MA,etc.Cdk5 regulates the phosphorylation of tyrosine 1472 NR2B and the surface expression of NMDA receptors.[J].2008,28(2).
[70]Pant HC,Albers W,Amin ND.Cyclin-dependent kinase 5 (cdk5) activation requires interaction with three domains of p35.[J].2002,67(3).
[71]Wenk MR,Kim Y,De Camilli P,etc.Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses[J].2004,101(2).
[72]Wang X,Wiedmann M,Blair LA,etc.Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis.[J].2003,38(1).
[73]Peris L,Quiroga S,Paglini G,etc.The Cdk5-p35 kinase, associates with the Golgi apparatus and regulates membrane traffic[J].2001,2(12).
[74]G N, Patrick,L, Zukerberg,M, Nikolic,etc.Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration.[J].1999,402(6762).
[75]Ishiguro K,Pant HC,Wei FY,etc.Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability.[J].2005,93(2).
[76]R, Nath,M, Davis,A W, Probert,etc.Processing of cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells.[J].2000,274(1).
[77]Verdaguer E,Pallas M,Camins A,etc.The role of CDK5/P25 formation/inhibition in neurodegeneration.[J].2006,19(8).
[78]J A, Bibb,J, Chen,J R, Taylor,etc.Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5.[J].2001,410(6826).
[79]Saito T,Konno T,Hosokawa T,etc.P25/Cyclin-Dependent Kinase 5 Promotes the Progression of Cell Death in Nucleus of Endoplasmic Reticulum-Stressed Neurons.[J].2007,102(1).
[80]M R, Hellmich,H C, Pant,E, Wada,etc.Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression.[J].1992,89(22).
[81]Li Qing,Lim HuiYing,Qi RobertZ,etc.The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity.[J].2002,277(9).
[82]K, Ishiguro,M, Takamatsu,K, Tomizawa,etc.Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments.[J].1992,267(15).
[83]Shunsuke Kobayashi,Koichi Ishiguro,Akira Omori,etc.A cdc2-related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline-directed protein kinase associated with microtubule[J].1993,335(2).
[84]M, Meyerson,G H, Enders,C L, Wu,etc.A family of human cdc2-related protein kinases.[J].1992,11(8).
[85]Smith DS,Tsai LH.Cdk5 behind the wheel: a role in trafficking and transport? [Review][J].2002,12(1).
[86]S, Hisanaga,M, Kusubata,E, Okumura,etc.Phosphorylation of neurofilament H subunit at the tail domain by CDC2 kinase dissociates the association to microtubules.[J].1991,266(32).
[87]Mark Moorthamer,Bhabatosh Chaudhuri.Identification of Ribosomal Protein L34 as a Novel Cdk5 Inhibitor[J].1999,255(3).
[88]J, Lew,Q Q, Huang,Z, Qi,etc.A brain-specific activator of cyclin-dependent kinase 5.[J].1994,371(6496).
[89]Zukerberg LR,Patrick GN,Nikolic M,etc.Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth (see comments)[J].2000,26(3).
[90]D R, Rosen,T, Siddique,D, Patterson,etc.Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis.[J].1993,362(6415).
[91]Evans GJ,Cousin MA.Activity-dependent control of slow synaptic vesicle endocytosis by cyclin-dependent kinase 5.[J].2007,27(2).
[92]T, Chae,Y T, Kwon,R, Bronson,etc.Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality.[J].1997,18(1).
[93]Assini A,Giliberto L,Smith MA,etc.Increase of cdk5 is related to neurofibrillary pathology in progressive supranuclear palsy.[J].2002,58(4).
[94]S L, Green,K S, Kulp,R, Vulliet.Cyclin-dependent protein kinase 5 activity increases in rat brain following ischemia.[J].1997,31(4).
[95]Hyman BT,Sanders JL,Augustinack JC,etc.Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles.[J].2002,61(6).
[96]Ahlijanian M,Veeranna,Dickson D,etc.Cdk5 is a key factor in tau aggregation and tangle formation in vivo.[J].2003,38(4).
[97]Tsai LH,Greer PL,Smith DS.Cdk5 on the brain.[J].2001,12(6).
[98]Krieger C,Hu JH,Pelech S.Aberrant protein kinases and phosphoproteins in amyotrophic lateral sclerosis.[J].2003,24(10).
[99]Dhariwala FA,Rajadhyaksha MS.An unusual member of the Cdk family: Cdk5.[J].2008,28(3).
[100]Ma W,Zhang L,Zheng Y,etc.Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival.[J].2003,278(37).
[101]Nguyen C,Benavides DR,Bibb JA,etc.Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation.[J].2007,10(7).
[102]Chergui K,Svenningsson P,Greengard P.Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum[J].2004,101(7).
[103]Fischer A,Spiess J,Schrick C,etc.Regulation of contextual fear conditioning by baseline and inducible septo-hippocampal cyclin-dependent kinase 5.[J].2003,44(8).