Roles of cyclin-dependent kinase 5 in central nervous system development and neurodegenerative diseases

( views:103, downloads:0 )
CHEN Jie()
WANG Zhong-Feng()
Journal Title:
Volume 62, Issue 04, 2010
Key Word:


  • [1]Hellmich MR,Pant HC,Wada E,Battey JF.Neuronal cdc2-like kinase:a cdc2-related protein kinase with predominantly neuronal expression.Proc Natl Acad Sci U S A 1992; 89 (22):10867-10871.
  • [2]Hisanaga S,Kusubata M,Okumura E,Kishimoto T.Phnsphorylation of neurofilament H subunit at the tail domain by CDC2 kinase dissociates the association to microtubules.J Biol Chem 1991; 266 (32):21798-21803.
  • [3]Meyerson M,Enders GH,Wu CL,Su LK,Gorka C,Nelson C,Harlow E,Tsai LH.A family of human cdc2-related protein kinases.EMBO J 1992; 11 (8):2909-2917.
  • [4]Lew J,Beaudette K,Litwin CM,Wang JH.Purification and characterization of a novel proline-directed protein kinase from bovine brain.J Biol Chem 1992; 267 (19):13383-13390.
  • [5]Lew J,Winkfein RJ,Paudel HK,Wang JH.Brain prolinedirected protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2.J Biol Chem 1992; 267 (36):25922-25926.
  • [6]Ishiguro K,Takamatsu M,Tomizawa K,Omori A,Takahashi M,Arioka M,Uchida T,Imahori K.Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments.J Biol Chem 1992; 267 (15):10897-10901.
  • [7]Kobayashi S,Ishiguro K,Omori A,Takamatsu M,Arioka M,Imahori K,Uchida T.A cdc2-related kinase PSSALRE/ cdk5 is homologous with the 30 kDa subunit of tau protein kinase Ⅱ,a proline-directed protein kinase associated with microtubule.FEBS Lett 1993; 335 (2):171-175.
  • [8]Dhariwala FA,Rajadhyaksha MS.An unusual member of the Cdk family:Cdk5.Cell Mol Neurobiol 2008; 28 (3):351-369.
  • [9]Lew J,Huang QQ,Qi Z,Winkfein RJ,Aebersold R,Hunt T,Wang JH.A brain-specific activator of cyclin-dependent kinase 5.Nature 1994; 371 (6496):423-426.
  • [10]Tsai LH,Delalle I,Caviness VS Jr,Chae T,Harlow E.p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5.Nature 1994; 371 (6496):419-423.
  • [11]Rosales JL,Lee KY.Extraneuronal roles of cyclin-dependent kinase 5.Bioessays 2006; 28 (10):1023-1034.
  • [12]Lin W,Dominguez B,Yang J,Aryal P,Brandon EP,Gage FH,Lee KF.Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism.Neuron 2005; 46 (4):569-579.
  • [13]Chen F,Qian L,Yang ZH,Huang Y,Ngo ST,Ruan NJ,Wang J,Schneider C,Noakes PG,Ding YQ,Mei L,Luo ZG.Rapsyn interaction with calpain stabilizes AChR clusters at the neuromuacular junction.Neuron 2007; 55 (2):247-260.
  • [14]Donnellan R,Chetty R.Cyclin E in human cancers.FASEB J 1999; 13 (8):773-780.
  • [15]Ko J,Humbert S,Bronson RT,Takahashi S,Kulkarni AB,Li E,Tsai LH.p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.J Neurosci 2001; 21 (17):6758-6771.
  • [16]Amin ND,Albers W,Pant HC.Cyclin-dependent kinase 5 (cdk5) activation requires interaction with three domains of p35.J Neurosci Res 2002; 67 (3):354-362.
  • [17]Hisanaga S,Saito T.The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator.Neurosignals 2003; 12 (4-5):221-229.
  • [18]Zheng M,Leung CL,Liem RK.Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators,p35 and p39,in the developing and adult rat central nervous system.J Neurobiol 1998; 35 (2):141-159.
  • [19]Wu DC,Yu YP,Lee NT,Yu AC,Wang JH,Han YF.The expression of Cdk5,p35,p39,and Cdk5 kinase activity in developing,adult,and aged rat brains.Neurochem Res 2000; 25 (7):923-929.
  • [20]Yamada M,Saito T,Sato Y,Kawai Y,Sekigawa A,Hamazumi Y,Asada A,Wada M,Doi H,Hisanaga S.Cdk5-39 is a labile complex with the similar substrate specificity to Cdk5-35.J Neurochem 2007; 102 (5):1477-1487.
  • [21]Asada A,Yamamoto N,Gohda M,Saito T,Hayashi N,Hisanaga S.Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclindependent kinase 5 complexes.J Neurochem 2008; 106 (3):1325-1336.
  • [22]Patrick GN,Zukerberg L,Nikolic M,de la Monte S,Dikkes P,Tsai LH.Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration.Nature 1999; 402 (6762):615-622.
  • [23]Chae T,Kwon YT,Bronson R,Dikkes P,Li E,Tsai LH.Mice lacking p35,a neuronal specific activator of Cdk5,display cortical lamination defects,seizures,and adult lethality.Neuron 1997; 18 (1):29-42.
  • [24]Ohshima T,Ward JM,Huh CG,Longenecker G,Veeranna,Pant HC,Brady RO,Martin L J,Kulkarni AB.Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis,neuronal pathology and perinatal death.Proc Nail Acad Sci U S A 1996; 93 (20):11173-11178.
  • [25]Delalle I,Bhide PG,Caviness VS Jr,Tsai LH.Temporal and spatial patterns of expression of p35,a regulatory subunit of cyclin-dependent kinase 5,in the nervous system of the mouse.J Neurocytol 1997; 26 (5):283-296.
  • [26]Hallows JL,Chen K,DePinho RA,Vincent I.Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice.J Neurosci 2003; 23 (33):10633-10644.
  • [27]Lee MS,Kwon YT,Li M,Peng J,Friedlander RM,Tsai LH.Neurotoxicity induces cleavage of p35 to p25 by calpain.Nature 2000; 405 (6784):360-364.
  • [28]Kusakawa G,Saito T,Onuki R,Ishiguro K,Kishimoto T,Hisanaga S.Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25.J Biol Chem 2000; 275 (22):17166-17172.
  • [29]Nath R,Davis M,Probert AW,Kupina NC,Ren X,Schielke GP,Wang KK.Processing of cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells.Biochem Biophys Res Commun 2000; 274 (1):16-21.
  • [30]Tarricone C,Dhavan R,Peng J,Areces LB,Tsai LH,Musacchio A.Structure and regulation of the CDK5-p25 (nck5a) complex.Mol Cell 2001; 8 (3):657-669.
  • [31]Patrick GN,Zhou P,Kwon YT,Howley PM,Tsai LH.p35,the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway.J Biol Chem 1998; 273 (37):24057-24064.
  • [32]Wei FY,Tomizawa K,Ohshima T,Asada A,Saito T,Nguyen C,Bibb JA,Ishiguro K,Kulkarni AB,Pant HC,Mikoshiba K,Matsui H,Hisanaga S.Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability.J Neurochem 2005; 93 (2):502-512.
  • [33]Chen J,Zhang Y,Kelz MB,Steffen C,Ang ES,Zeng L,Nestler EJ.Induction of cyclin-dependent kinase 5 in the hippocampus by chronic electroconvulsive seizures:role of[Delta]FosB.J Neurosci 2000; 20 (24):8965-8971.
  • [34]Tokuoka H,Saito T,Yorifuji H,Wei F,Kishimoto T,Hisanaga S.Brain-derived neurotrophic factor-induced phosphorylation of neurofilament-H subunit in primary cultures of embryo rat cortical neurons.J Cell Sci 2000; 113 (Pt 6):1059-1068.
  • [35]Smith DS,Greer PL,Tsai LH.Cdk5 on the brain.Cell Growth Differ 2001; 12 (6):277-283.
  • [36]Qu D,Li Q,Lim HY,Cheung NS,Li R,Wang JH,Qi RZ.The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity.J Biol Chem 2002; 277 (9):7324-7332.
  • [37]Moorthamer M,Chaudhuri B.Identification of ribosomal protein L34 as a novel Cdk5 inhibitor.Biochem Biophys Res Commun 1999; 255 (3):631-638.
  • [38]Moorthamer M,Zumstein-Mecker S,Chaudhuri B.DNA binding protein dbpA binds Cdk5 and inhibits its activity.FEBS Lett 1999; 446 (2-3):343-350.
  • [39]Sharma P,Sharma M,Amin ND,Albers RW,Pant HC.Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation.Proc Natl Acad Sci U S A 1999; 96 (20):11156-11160.
  • [40]Tsai LH,Takahashi T,Caviness VS Jr,Harlow E.Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system.Development 1993; 119 (4):1029-1040.
  • [41]Hirooka K,Tomizawa K,Matsui H,Tokuda M,Itano T,Hasegawa E,Wang JH,Hatase O.Developmental alteration of the expression and kinase activity of cyclin-dependent kinase 5 (Cdk5)/p35nck5a in the rat retina.J Neurochem 1996; 67 (6):2478-2483.
  • [42]Grant P,Sharma P,Pant HC.Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolism.Eur J Biochem 2001; 268 (6):1534-1546.
  • [43]Niethammer M,Smith DS,Ayala R,Peng J,Ko J,Lee MS,Morabito M,Tsai LH.NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein.Neuron 2000; 28 (3):697-711.
  • [44]Lambert de Rouvroit C,Goffinet AM.Neuronal migration.Mech Dev 2001; 105 (1-2):47-56.
  • [45]Feng Y,Walsh CA.Protein-protein interactions,cytoskeletal regulation and neuronal migration.Nat Rev Neurosci 2001; 2 (6):408-416.
  • [46]Aboitiz F,Montiel J,Lopez J.An hypothesis on the early evolution of the development of the isocortex.Brain Res Bull 2002; 57 (3-4):481-483.
  • [47]Gilmore EC,Herrup K.Neocortical cell migration:GABAergic neurons and cells in layersⅠ and Ⅵ move in a cyclin-dependent ldnase 5-independent manner.J Neurosci 2001; 21 (24):9690-9700.
  • [48]Xie Z,Sanada K,Samuels BA,Shih H,Tsai LH.Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization,nuclear movement,and neuronal migration.Cell 2003; 114(4):469-482.
  • [49]Tanaka T,Serneo FF,Tseng HC,Kulkarni AB,Tsai LH,Gleeson JG.Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration.Neuron 2004; 41 (2):215-227.
  • [50]Nikolic M,Dudek H,Kwon YT,Ramos YF,Tsal LH.The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.Genes Dev 1996; 10 (7):816-825.
  • [51]Kwon YT,Tsai LH,Crandall JE.Callosal axon guidance defects in p35(-/-) mice.J Comp Neurol 1999; 415 (2):218-229.
  • [52]Li BS,Zhang L,Gu J,Amin ND,Pant HC.Integrin alpha(1) beta(1)-mediated activation of cyclin-dependent kinase 5 activity is involved in neurite outgrowth and human reurofilament protein H Lys-Ser-Pro tail domain phosphorylation.J Neurosci 2000; 20 (16):6055-6062.
  • [53]Zukerberg LR,Patrick GN,Nikolic M,Humbert S,Wu CL,Lanier LM,Gertler FB,Vidal M,Van Etten RA,Tsai LH.Cables finks Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation,kinase upregulation,and neurite outgrowth.Neuron 2000; 26 (3):633-646.
  • [54]Fu WY,Chen Y,Sahin M,Zhao XS,Shi L,Bikoff JB,Lai KO,Yung WH,Fu AK,Greenberg ME,Ip NY.Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism.Nat Neurosci 2007; 10(1):67-76.
  • [55]Cheung ZH,Chin WH,Chen Y,Ng YP,Ip NY.Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons.PLoS Biol 2007; 5 (4):e63.
  • [56]Cheung ZH,Ip NY.The roles of cyclin-dependent kinase 5 in dendrite and synapse development.Biotechnol J 2007; 2 (8):949-957.
  • [57]Fletcher AI,Shuang R,Giovannucci DR,Zhang L,Bittner MA,Stuenkel EL.Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc 18.J Biol Chem 1999; 274 (7):4027-4035.
  • [58]Tomizawa K,Ohta J,Matsushita M,Moriwaki A,Li ST,Takei K,Matsui H.Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/ Q-type voltage-dependent calcium channel activity.J Neurosci 2002; 22 (7):2590-2597.
  • [59]Chergui K,Svenningsson P,Greengard P.Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum.Proc Nail Acad Sci USA 2004; 101 (7):2191-2196.
  • [60]Amin ND,Zheng YL,Kesavapany S,Kanungo J,Gnszczynski T,Sihag RK,Rudrahhatla P,Albers W,Grant P,Pant HC.Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosis.J Neurosci 2008; 28 (14):3631-3643.
  • [61]Floyd SR,Porro EB,Slepnev Ⅵ,Ochoa GC,Tsai LH,De Camilli P.Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2.J Biol Chem 2001; 276 (11):8104-8110.
  • [62]Tan TC,Valova VA,MaUadi CS,Graham ME,Berven LA,Jupp OJ,Hansra G,McClure SJ,Sarcevic B,Boadle RA,Larsen MR,Cousin MA,Robinson PJ.Cdk5 is essential for synaptic vesicle endocytosis.Nat Cell Biol 2003; 5 (8):701-710.
  • [63]Lee SY,Wenk MR,Kim Y,Nairn AC,De Camilli P.Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses.Proc Natl Acad Sci U S A 2004; 101 (2):546-551.
  • [64]Evans GJ,Cousin MA.Activity-dependent control of slow synaptic vesicle endocytosis by cyclin-dependent kinase 5.J Neurosci 2007; 27 (2):401-411.
  • [65]Paglini G,Peris L,Diez-Gnerra J,Quiroga S,Caceres A.The Cdk5-p35 kinase associates with the Golgi apparatus and regulates membrane traffic.EMBO Rep 2001; 2 (12):1139-1144.
  • [66]Smith DS,Tsai LH.Cdk5 behind the wheel:a role in trafficking and transport? Trends Cell Biol 2002; 12 (1):28-36.
  • [67]Shea TB,Yabe JT,Ortiz D,Pimenta A,Loomis P,Goldman RD,Amin N,Pant HC.Cdk5 regulates axonal transport and phosphorylation of neurofilaments in cultured neurons.J Cell Sci 2004; 117 (Pt 6):933-941.
  • [68]Fu AK,Fu WY,Cheung J,Tsim KW,Ip FC,Wang JH,Ip NY.Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction.Nat Neurosci 2001; 4 (4):374-381.
  • [69]Li BS,Sun MK,Zhang L,Takahashi S,Ma W,Vinade L,Kulkarni AB,Brady RO,Pant HC.Regulation of NMDA receptors by cyclin-dependent kinase-5.Proc Nail Acad Sci U S A 2001; 98 (22):12742-12747.
  • [70]Hawasli AH,Benavides DR,Nguyen C,Kansy JW,Hayashi K,Chambon P,Greengard P,Powell CM,Cooper DC,Bibb JA.Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation.Nat Neurosci 2007; 10 (7):880-886.
  • [71]Zhang S,Edelmann L,Liu J,Crandall JE,Morabito MA.Cdk5 regulates the phosphorylation of tyrosine 1472 NR2B and the surface expression of NMDA receptors.J Neurosci 2008; 28 (2):415-424.
  • [72]Fischer A,Sananbenesi F,Schrick C,Spiess J,Radulovic J.Cyclin-dependent kinase 5 is required for associative learning.J Neurosci 2002; 22 (9):3700-3707.
  • [73]Fischer A,Sananbenesi F,Schrick C,Spiess J,Radulovic J.Regnlation of contextual fear conditioning by baseline and inducible septo-hippocampal cyclin-dependent kinase 5.Neuropharmacology 2003; 44 (8):1089-1099.
  • [74]Ohshima T,Ogura H,Tomizawa K,Hayashi K,Suzuki H,Saito T,Kamei H,Nishi A,Bibb JA,Hisanaga S,Matsui H,Mikoshiba K.Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice.J Neurochem 2005; 94 (4):917-925.
  • [75]Fischer A,Sananbenesi F,Pang PT,Lu B,Tsai LH.Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory.Neuron 2005; 48 (5):825-838.
  • [76]Pareek TK,Keller J,Kesavapany S,Pant HC,Iadarola MJ,Brady RO,Kulkarni AB.Cyclin-depondent kinase 5 activity regulates pain signaling.Proc Nail Acad Sci U S A 2006; 103 (3):791-796.
  • [77]Wang CH,Chou WY,Hung KS,Jawan B,Lu CN,Liu JK,Hung YP,Lee TH.Intrathecal administration of roscovitine inhibits Cdk5 activity and attenuates formalin-induced nociceptive response in rats.Acta Pharmacol Sin 2005; 26 (1):46-50.
  • [78]Bibb JA,Chen J,Taylor JR,Svenningsson P,Nishi A,Snyder GL,Yan Z,Sagawa ZK,Ouimet CC,Nairn AC,Nestler EJ,Greengard P.Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5.Nature 2001; 410 (6826):376-380.
  • [79]Bibb JA.Role of Cdk5 in neuronal signaling,plasticity,and drug abuse.Neurosignals 2003; 12 (4-5):191-199.
  • [80]Zhang Q,Ahuja HS,Zakeri ZF,Wolgemuth DJ.Cyclindependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling.Dev Biol 1997; 183 (2):222-233.
  • [81]Gao C,Negash S,Wang MS,Ledee D,Guo H,Russell P,Zelenka P.Cdk5 mediates changes in morphology and promotes apoptosis of astrocytoma cells in response to heat shock.J Cell Sci 2001; 114 (Pt 6):1145-1153.
  • [82]Weishaupt JH,Kussmaul L,Grotsch P,Heckel A,Rohde G,Romig H,Bahr M,Gillardon F.Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction.Mol Cell Neurosci 2003; 24 (2):489-502.
  • [83]Neystat M,Rzhetskaya M,Oo TF,Kholodilov N,Yarygina O,Wilson A,El-Khodor BF,Burke RE.Expression of cyclindependent kinase 5 and its activator p35 in models of induced apoptotic death in neurons of the substantia nigra in vivo.J Neurochem 2001; 77 (6):1611-1625.
  • [84]Lin H,5uang JL,Wang PS.Involvement of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis.J Biol Chem 2004; 279 (28):29302-29307.
  • [85]Hamdane M,Bretteville A,Sambo AV,Schindowski K,Begard S,Delacourte A,Bertrand P,Buee L.p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death.J Cell Sci 2005; 118 (Pt 6):1291-1298.
  • [86]Saito T,Konno T,Hosokawa T,Asada A,Ishiguro K,Hisanaga S.p25/cyclin-dependent kinase 5 promotes the progression of cell death in nucleus of endoplasmic reticulure-stressed neurons.J Neurochem 2007; 102 (1):133-140.
  • [87]Camins A,Verdaguer E,Folch J,Canudas AM,Pallas M.The role of CDK5/P25 formation/inhibition in neurodegeneration.Drug News Perspect 2006; 19 (8):453-460.
  • [88]Wang J,Liu S,Fu Y,Wang JH,Lu Y.Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors.Nat Neurosci 2003; 6 (10):1039-1047.
  • [89]Gong X,Tang X,Wiedmann M,Wang X,Peng J,Zheng D,Blair LA,Marshall J,Mao Z.Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis.Neuron 2003; 38 (1):33-46.
  • [90]Cruz JC,Tsai LH.A Jekyll and Hyde kinase:roles for Cdk5 in brain development and disease.Curr Opin Neurobiol 2004; 14 (3):390-394.
  • [91]Dhavan R,Tsai LH.A decade of CDK5.Nat Rev Mol Cell Biol 2001; 2 (10):749-759.
  • [92]Li BS,Ma W,Jaffe H,Zheng Y,Takahashi S,Zhang L,Kulkarni AB,Pant HC.Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival.J Biol Chem 2003; 278 (37):35702-35709.
  • [93]Cheung ZH,Gong K,Ip NY.Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2.J Neurosci 2008; 28 (19):4872-4877.
  • [94]Wang CX,Song JH,Song DK,Yong VW,Shuaib A,Hao C.Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2.Cell Death Differ 2006; 13 (7):1203-1212.
  • [95]Tanaka T,Veeranna,Ohshima T,Rajah P,Amin ND,Cho A,Sreenath T,Pant HC,Brady RO,Kulkarni AB.Neuronal cyclin-dependent kinase 5 activity is critical for survival.J Neurosci 2001; 21 (2):550-558.
  • [96]Otth C,Concha,Ⅱ,Arendt T,Stieler J,Schliebs R,GonzalezBillault C,Maccioni RB.AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenie mice Tg2576.J Alzheimers Dis 2002; 4 (5):417-430.
  • [97]Cai X,Tang D,Xu R.Neuronal cdc-2 like kinase in developing kindling rat hippocampus.Chin Med J (Engl) 2001; 114 (3):248-252.
  • [98]Green SL,Kulp KS,Vulliet R.Cyclin-dependent protein kinase 5 activity increases in rat brain following ischemia.Neurochem Int 1997; 31 (4):617-623.
  • [99]Rashidian J,Iyirhiaro G,Aleyasin H,Rios M,Vincent I,Callaghan S,Bland RJ,Slack RS,During MJ,Park DS.Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo.Proc Natl Acad Sci U S A 2005; 102 (39):14080-14085.
  • [100]O'Hare MJ,Kushwaha N,Zhang Y,Aleyasin H,Callaghan SM,Slack RS,Albert PR,Vincent I,Park DS.Differential roles of nuclear and cytoplasmic cyclin-dependont kinase 5 in apoptotic and excitotoxic neuronal death.J Neurosci 2005; 25 (39):8954-8966.
  • [101]Namgung U,Choi BH,Park S,Lee JU,Seo HS,Suh BC,Kim KT.Activation of cyclin-dependent kinase 5 is involved in axonal regeneration.Mol Cell Neurosci 2004; 25 (3):422-432.
  • [102]Alvarez A,Toro R,Caceres A,Maccioni RB.Inhibition of tan phosphorylating protein kinase edk5 prevents beta-amyloid-induced neuronal death.FEBS Lett 1999; 459 (3):421-426.
  • [103]Alvarez A,Munoz JP,Maccioni RB.A CdkS-p35 stable complex is involved in the beta-amyloid-induced deregulation of Cdk5 activity in hippocampal neurons.Exp Cell Res 2001; 264 (2):266-274.
  • [104]Kesavapany S,Lau KF,McLoughlin DM,Brownlees J,Ackerley S,Leigh PN,Shaw CE,Miller CC.p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/ presenilin-1 interaction.Eur J Neurosci 2001; 13 (2):241-247.
  • [105]Tseng HC,Zhou Y,Shen Y,Tsai LH.A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains.FEBS Lett 2002; 523 (1-3):58-62.
  • [106]Augustinack JC,Sanders JL,Tsai LH,Hyman BT.Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in preneurofibrillary tangles and neurofibrillary tangles.J Neuropathol Exp Neurol 2002; 61 (6):557-564.
  • [107]Cruz JC,Tseng HC,Goldman JA,Shih H,Tsai LH.Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles.Neuron 2003; 40 (3):471-483.
  • [108]Noble W,Olm V,Takata K,Casey E,Mary O,Meyerson J,Gaynor K,LaFrancois J,Wang L,Kondo T,Davies P,Burns M,Veeranna,Nixon R,Dickson D,Matsuoka Y,Ahlijanian M,Lau LF,Duff K.Cdk5 is a key factor in tau aggregation and tangle formation in vivo.Neuron 2003; 38 (4):555-565.
  • [109]Smith PD,Crocker S J,Jackson-Lewis V,Jordan-Scintto KL,Hayley S,Mount MP,O'Hare are MJ,Callaghan S,Slack RS,Przedborski S,Anisman H,Park DS.Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease.Proc Natl Acad Sci U S A 2003; 100 (23):13650-13655.
  • [110]Borghi R,Giliberto L,Assini A,Delacourte A,Perry G,Smith MA,Strocchi P,Zaccheo D,Tabaton M.Increase of cdk5 is related to neurofibrillary pathology in progressive supranuclear palsy.Neurology 2002; 58 (4):589-592.
  • [111]Bu B,Li J,Davies P,Vincent I.Deregulation of cdk5,hyperphosphorylation,and cytoskeletal pathology in the Niemann-Pick type C murine model.J Neurosci 2002; 22 (15):6515-6525.
  • [112]Luo S,Vacher C,Davies JE,Rubinsztein DC.Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases:implications for mutant huntingtin toxicity.J Cell Biol 2005; 169 (4):647-656.
  • [113]Rosen DR,Siddique T,Patterson D,Figlewicz DA,Sapp P,Hentati A,Donaldson D,Goto J,O'Regan JP,Deng HX,Rahmani Z,Krizus A,McKenna-Yasek D,Cayabyab A,Gaston SM,Berger R,Tanzi RE,Halperin JJ,Herzfeldt B,Van den Bergh R,Hung WY,Bird T,Deng G,Mulder DW,Smyth C,Laing NG,Soriano E,Pericak-Vance MA,Haines J,Rouleau GA,Gusella JS,Horvitz HR,Brown RH Jr.Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis.Nature 1993; 362 (6415):59-62.
  • [114]Patzke H,Tsai LH.Cdk5 sinks into ALS.Trends Neurosci 2002; 25 (1):8-10.
  • [115]Krieger C,Hu JH,Pelech S.Aberrant protein kinases and phosphoproteins in amyotrophic lateral sclerosis.Trends Pharmacol Sci 2003; 24 (10):535-541.
  • [116]Nguyen MD,Boudreau M,Kriz J,Couillard-Despres S,Kaplan DR,Julien JP.Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1.J Neurosci 2003; 23 (6):2131-2140.
  • [117]Ngnyen MD,Julien JP.Cyclin-dependent kinase 5 in amyotrophic lateral sclerosis.Neurosignals 2003; 12 (4-5):215-220.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615