LASS2 interacts with V-ATPase and inhibits cell growth of hepatocellular carcinoma

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TANG Ning()
JIN Jie()
DENG Yun()
KE Rong-Hu()
SHEN Qiu-Jin()
FAN Shao-Hua()
QIN Wen-Xin()
Journal Title:
Volume 62, Issue 03, 2010
Key Word:


  • [1]Jiang JC,Kirchman PA,Zagulski M,Hunt J,Jazwinski SM.Homologs of the yeast longevity gene LAGl in Caenorhabditis elegans and Human.Genome Res 1998; 8(12):1259-1272.
  • [2]Pan H,Qin WX,Huo KK,Wan DF,Yu Y,Xu ZG,Hu QD,Gu KT,Zhou XM,Jiang HQ,Zhang PP,Huang Y,Li YY,Gu JR.Cloning,mapping,and characterization of a human homologue of the yeast longevity assurance gene LAG1.Genomics 2001; 77 (1-2):58-64.
  • [3]Nishi T,Forgac M.The vacuolar (H+)-ATPases-nature's most versatile proton pumps.Nat Rev Mol Cell Biol 2002; 3(2):94-103.
  • [4]Finbow ME,Harrison MA.The vacuolar H+-ATPase:a universal proton pump of eukaryotes.Biochem J 1997; 324(Pt 3):697-712.
  • [5]Williams AC,Collard TJ,Paraskeva C.An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines:implications for clonal selection during colorectal carcinogenesis.Oncogene 1999; 18(21):3199-3204.
  • [6]Kyriakis JM,Banerjee P,Nikolakaki E,Dai T,Rubie EA,Ahmad MF,Avruch J,Woodgett JR.The stress-activated protein kinase subfamily of c-Jun kinases.Nature 1994; 369(6476):156-160.
  • [7]Zou H,Li Y,Liu X,Wang X.An APAF-1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9.J Biol Chem 1999; 274(17):11549-11556.
  • [8]Reed JC.Cytochrome c:can't live with it-can't live without it.Cell 1997; 91(5):627-637.
  • [9]Oltivai ZN,Miliman CL,Korsmeyer SJ.Bcl-2 heterodimerizes in vivo with conserved homolog,Bax,that accelerates programmed cell death.Cell 1993; 74(4):609-619.
  • [10]Tan N (谭宁),Qin WX,Wan XZ,Yu YJ,Wang ZR,Gu JR.LASS2 inhibits the metastasis of human hepatocellular carcinoma cells.Tumor (肿瘤) 2007; 27(5):335-340 (Chinese,English abstract).
  • [11]Shai S,Nathan N.Vacuolar H+-ATPase-an enzyme for all seasons.Pflugers Arch 2009; 457(3):581-587.
  • [12]Lu X,Qin W,Li J,Tan N,Pan D,Zhang H,Xie L,Yao G,Shu H,Yao M,Wan D,Gu J,Yang S.The growth and metastasis of human hepatocellular carcinoma xenografts are inhibited by small interfering RNA targeting to the subunit ATP6L of proton pump.Cancer Res 2005; 65(15):6843-6849.
  • [13]Kubasiak LA,Hernandez OM,Bishopric NH,Webster KA.Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3.Proc Natl Acad Sci U S A 2002; 99(22):12825-12830.
  • [14]Kumar S,Kasseekert S,Kostin S,Abdallah Y,Schafer C,Kaminski A,Reusch HP,Piper HM,Steinhoff G,Ladilov Y.Ischemic acidosis causes apoptosis in coronary endothelial cells through activation of caspase-12.Cardiovasc Res 2007;73(1):172-180.
  • [15]Liu X,Kim CN,Yang J,Jemmerson R,Wang X.Induction of apoptotic program in cell-free extracts:requirement for dATP and cytochrome c.Cell 1996; 86(1):147-157.
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